3bwp: Difference between revisions

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[[Image:3bwp.~~jpg~~|left|200px]]

[[Image:3bwp.png|left|200px]]

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~~'''~~Crystal structure of a self-spliced group II intron~~'''~~

===Crystal structure of a self-spliced group II intron===

~~==Overview==~~

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~~Group II introns are self-splicing ribozymes that catalyze their own excision from precursor transcripts and insertion into new genetic locations. Here we report~~ the ~~crystal structure of an intact, self-spliced group II intron from Oceanobacillus iheyensis~~ at 3.~~1 angstrom resolution~~. An extensive network of tertiary interactions facilitates the ordered packing of intron subdomains around a ribozyme core that includes catalytic domain V. The bulge of domain V adopts an unusual helical structure that is located adjacent to a major groove triple helix (catalytic triplex)~~. The bulge and catalytic triplex jointly coordinate two divalent metal ions in a configuration that~~ is ~~consistent with a two-metal ion mechanism for catalysis. Structural and functional analogies support the hypothesis that group II introns and~~ the ~~spliceosome share a common ancestor~~.

The line below this paragraph, {{ABSTRACT_PUBMED_18388288}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 18388288 is the PubMed ID number.

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==About this Structure==

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[[Category: Ribonucleic acid]]

[[Category: Rna]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Apr 16 23~~:13:05 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:33:30 2008''

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-[[Image:3bwp.jpg|left|200px]]
+{{Seed}}
+[[Image:3bwp.png|left|200px]]
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 {{STRUCTURE_3bwp|  PDB=3bwp  |  SCENE=  }}
-'''Crystal structure of a self-spliced group II intron'''
+===Crystal structure of a self-spliced group II intron===
-==Overview==
+<!--
-Group II introns are self-splicing ribozymes that catalyze their own excision from precursor transcripts and insertion into new genetic locations. Here we report the crystal structure of an intact, self-spliced group II intron from Oceanobacillus iheyensis at 3.1 angstrom resolution. An extensive network of tertiary interactions facilitates the ordered packing of intron subdomains around a ribozyme core that includes catalytic domain V. The bulge of domain V adopts an unusual helical structure that is located adjacent to a major groove triple helix (catalytic triplex). The bulge and catalytic triplex jointly coordinate two divalent metal ions in a configuration that is consistent with a two-metal ion mechanism for catalysis. Structural and functional analogies support the hypothesis that group II introns and the spliceosome share a common ancestor.
+The line below this paragraph, {{ABSTRACT_PUBMED_18388288}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18388288 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18388288}}
 ==About this Structure==
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 [[Category: Ribonucleic acid]]
 [[Category: Rna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 16 23:13:05 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:33:30 2008''