2f5k: Difference between revisions

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[[Image:2f5k.gif|left|200px]]
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[[Image:2f5k.png|left|200px]]


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{{STRUCTURE_2f5k|  PDB=2f5k  |  SCENE=  }}  
{{STRUCTURE_2f5k|  PDB=2f5k  |  SCENE=  }}  


'''Crystal structure of the chromo domain of human MRG15'''
===Crystal structure of the chromo domain of human MRG15===




==Overview==
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Human MRG15 is a transcription factor that plays a vital role in embryonic development, cell proliferation and cellular senescence. It comprises a putative chromo domain in the N-terminal part that has been shown to participate in chromatin remodeling and transcription regulation. We report here the crystal structure of human MRG15 chromo domain at 2.2 A resolution. The MRG15 chromo domain consists of a beta-barrel and a long alpha-helix and assumes a structure more similar to the Drosophila MOF chromo barrel domain than the typical HP1/Pc chromo domains. The beta-barrel core contains a hydrophobic pocket formed by three conserved aromatic residues Tyr26, Tyr46 and Trp49 as a potential binding site for a modified residue of histone tail. However, the binding groove for the histone tail seen in the HP1/Pc chromo domains is pre-occupied by an extra beta-strand. In vitro binding assay results indicate that the MRG15 chromo domain can bind to methylated Lys36, but not methylated Lys4, Lys9 and Lys27 of histone H3. These data together suggest that the MRG15 chromo domain may function as an adaptor module which can bind to a modified histone H3 in a mode different from that of the HP1/Pc chromo domains.
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{{ABSTRACT_PUBMED_17135209}}


==About this Structure==
==About this Structure==
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[[Category: Beta barrel]]
[[Category: Beta barrel]]
[[Category: Gene regulation]]
[[Category: Gene regulation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:29:10 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:37:00 2008''

Revision as of 16:37, 28 July 2008

File:2f5k.png

Template:STRUCTURE 2f5k

Crystal structure of the chromo domain of human MRG15

Template:ABSTRACT PUBMED 17135209

About this Structure

2F5K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3., Zhang P, Du J, Sun B, Dong X, Xu G, Zhou J, Huang Q, Liu Q, Hao Q, Ding J, Nucleic Acids Res. 2006;34(22):6621-8. Epub 2006 Nov 28. PMID:17135209

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