1pd3: Difference between revisions

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[[Image:1pd3.~~gif~~|left|200px]]

[[Image:1pd3.png|left|200px]]

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~~'''~~Influenza A NEP M1-binding domain~~'''~~

===Influenza A NEP M1-binding domain===

~~==Overview==~~

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~~During influenza virus infection~~, ~~viral ribonucleoproteins (vRNPs) are replicated in~~ the ~~nucleus and must be exported~~ to the ~~cytoplasm before assembling into mature viral particles. Nuclear export is mediated by the cellular protein Crm1 and putatively by the viral protein NEP~~/~~NS2. Proteolytic cleavage of NEP defines an N-terminal domain which mediates RanGTP-dependent binding to Crm1 and a C-terminal domain which binds to the viral matrix protein M1~~. ~~The 2~~.6 A crystal structure of the C-terminal domain reveals an amphipathic helical hairpin which dimerizes as a four-helix bundle. The NEP-M1 interaction involves two critical epitopes: an exposed tryptophan (Trp78) ~~surrounded by a cluster of glutamate residues on NEP~~, ~~and~~ the ~~basic nuclear localization signal (NLS) of M1. Implications for vRNP export are discussed~~.

The line below this paragraph, {{ABSTRACT_PUBMED_12970177}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12970177 is the PubMed ID number.

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==About this Structure==

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[[Category: Influenza virus some]]

[[Category: Nep/ns2]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 04~~:57:15 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:50:11 2008''

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-[[Image:1pd3.gif|left|200px]]
+{{Seed}}
+[[Image:1pd3.png|left|200px]]
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 {{STRUCTURE_1pd3|  PDB=1pd3  |  SCENE=  }}
-'''Influenza A NEP M1-binding domain'''
+===Influenza A NEP M1-binding domain===
-==Overview==
+<!--
-During influenza virus infection, viral ribonucleoproteins (vRNPs) are replicated in the nucleus and must be exported to the cytoplasm before assembling into mature viral particles. Nuclear export is mediated by the cellular protein Crm1 and putatively by the viral protein NEP/NS2. Proteolytic cleavage of NEP defines an N-terminal domain which mediates RanGTP-dependent binding to Crm1 and a C-terminal domain which binds to the viral matrix protein M1. The 2.6 A crystal structure of the C-terminal domain reveals an amphipathic helical hairpin which dimerizes as a four-helix bundle. The NEP-M1 interaction involves two critical epitopes: an exposed tryptophan (Trp78) surrounded by a cluster of glutamate residues on NEP, and the basic nuclear localization signal (NLS) of M1. Implications for vRNP export are discussed.
+The line below this paragraph, {{ABSTRACT_PUBMED_12970177}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12970177 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12970177}}
 ==About this Structure==
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 [[Category: Influenza virus some]]
 [[Category: Nep/ns2]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:57:15 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:50:11 2008''