1nnp: Difference between revisions

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[[Image:1nnp.gif|left|200px]]
{{Seed}}
[[Image:1nnp.png|left|200px]]


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{{STRUCTURE_1nnp|  PDB=1nnp  |  SCENE=  }}  
{{STRUCTURE_1nnp|  PDB=1nnp  |  SCENE=  }}  


'''X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.9 A resolution. Crystallization without zinc ions.'''
===X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.9 A resolution. Crystallization without zinc ions.===




==Overview==
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Two X-ray structures of the GluR2 ligand-binding core in complex with (S)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid ((S)-ATPA) have been determined with and without Zn(2+) ions. (S)-ATPA induces a domain closure of ca. 21 degrees compared to the apo form. The tert-butyl moiety of (S)-ATPA is buried in a partially hydrophobic pocket and forces the ligand into the glutamate-like binding mode. The structures provide new insight into the molecular basis of agonist selectivity between AMPA and kainate receptors.
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(as it appears on PubMed at http://www.pubmed.gov), where 12593667 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12593667}}


==About this Structure==
==About this Structure==
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[[Category: Ionotropic glutamate receptor glur2]]
[[Category: Ionotropic glutamate receptor glur2]]
[[Category: Ligand-binding core]]
[[Category: Ligand-binding core]]
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