1usi: Difference between revisions

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[[Image:1usi.~~jpg~~|left|200px]]

[[Image:1usi.png|left|200px]]

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~~'''~~L-LEUCINE-BINDING PROTEIN WITH PHENYLALANINE BOUND~~'''~~

===L-LEUCINE-BINDING PROTEIN WITH PHENYLALANINE BOUND===

~~==Overview==~~

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The ~~periplasmic leucine-binding protein is~~ the ~~primary receptor for~~ the ~~leucine transport system in Escherichia coli. We report here the structure of an open ligand-free form solved by molecular replacement and refined~~ at 1.~~5-A resolution~~. ~~In addition~~, ~~two closed ligand-bound structures of~~ the ~~same protein are presented, a phenylalanine-bound form at 1~~.~~8 A and a leucine~~-bound structure at a nominal resolution of 2.4 A. These structures show the basis of this protein's ligand specificity, as well as illustrating the conformational changes that are associated with ligand binding. Comparison with earlier structures provides further information about solution conformations, as well as the different specificity of the closely related leucine/isoleucine/valine-~~binding protein.~~

The line below this paragraph, {{ABSTRACT_PUBMED_14672931}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 14672931 is the PubMed ID number.

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==About this Structure==

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[[Category: Transport protein]]

[[Category: X-ray crystallography]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 11~~:37:44 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:59:07 2008''

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-[[Image:1usi.jpg|left|200px]]
+{{Seed}}
+[[Image:1usi.png|left|200px]]
 <!--
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 {{STRUCTURE_1usi|  PDB=1usi  |  SCENE=  }}
-'''L-LEUCINE-BINDING PROTEIN WITH PHENYLALANINE BOUND'''
+===L-LEUCINE-BINDING PROTEIN WITH PHENYLALANINE BOUND===
-==Overview==
+<!--
-The periplasmic leucine-binding protein is the primary receptor for the leucine transport system in Escherichia coli. We report here the structure of an open ligand-free form solved by molecular replacement and refined at 1.5-A resolution. In addition, two closed ligand-bound structures of the same protein are presented, a phenylalanine-bound form at 1.8 A and a leucine-bound structure at a nominal resolution of 2.4 A. These structures show the basis of this protein's ligand specificity, as well as illustrating the conformational changes that are associated with ligand binding. Comparison with earlier structures provides further information about solution conformations, as well as the different specificity of the closely related leucine/isoleucine/valine-binding protein.
+The line below this paragraph, {{ABSTRACT_PUBMED_14672931}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14672931 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14672931}}
 ==About this Structure==
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 [[Category: Transport protein]]
 [[Category: X-ray crystallography]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:37:44 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:59:07 2008''