2h6s: Difference between revisions

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[[Image:2h6s.~~jpg~~|left|200px]]

[[Image:2h6s.png|left|200px]]

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~~'''~~Secreted aspartic proteinase (Sap) 3 from Candida albicans~~'''~~

===Secreted aspartic proteinase (Sap) 3 from Candida albicans===

~~==Overview==~~

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The ~~family of secreted aspartic proteinases~~ (~~Sap) encoded by 10 SAP genes is an important virulence factor during Candida albicans (C~~. ~~albicans~~) ~~infections. Antagonists to Saps could be envisioned to help prevent or treat candidosis in immunocompromised patients. The knowledge of several Sap structures~~ is ~~crucial for inhibitor design; only~~ the ~~structure of Sap2 is known~~. ~~We report the 1.9 and 2.2 A resolution X~~-ray crystal structures of Sap3 in a stable complex with pepstatin A and in the absence of an inhibitor, shedding further light on the enzyme inhibitor binding. Inhibitor binding causes active site closure by the movement of a flap segment. Comparison of the structures of Sap3 and Sap2 identifies elements responsible for the specificity of each isoenzyme.

The line below this paragraph, {{ABSTRACT_PUBMED_17510964}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17510964 is the PubMed ID number.

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==About this Structure==

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[[Category: Aspartic proteinase]]

[[Category: Hydrolase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 05~~:56:13 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:01:52 2008''

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-[[Image:2h6s.jpg|left|200px]]
+{{Seed}}
+[[Image:2h6s.png|left|200px]]
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 {{STRUCTURE_2h6s|  PDB=2h6s  |  SCENE=  }}
-'''Secreted aspartic proteinase (Sap) 3 from Candida albicans'''
+===Secreted aspartic proteinase (Sap) 3 from Candida albicans===
-==Overview==
+<!--
-The family of secreted aspartic proteinases (Sap) encoded by 10 SAP genes is an important virulence factor during Candida albicans (C. albicans) infections. Antagonists to Saps could be envisioned to help prevent or treat candidosis in immunocompromised patients. The knowledge of several Sap structures is crucial for inhibitor design; only the structure of Sap2 is known. We report the 1.9 and 2.2 A resolution X-ray crystal structures of Sap3 in a stable complex with pepstatin A and in the absence of an inhibitor, shedding further light on the enzyme inhibitor binding. Inhibitor binding causes active site closure by the movement of a flap segment. Comparison of the structures of Sap3 and Sap2 identifies elements responsible for the specificity of each isoenzyme.
+The line below this paragraph, {{ABSTRACT_PUBMED_17510964}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17510964 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17510964}}
 ==About this Structure==
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 [[Category: Aspartic proteinase]]
 [[Category: Hydrolase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:56:13 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:01:52 2008''