2pbi: Difference between revisions

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[[Image:2pbi.~~jpg~~|left|200px]]

[[Image:2pbi.png|left|200px]]

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~~'''~~The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure~~'''~~

===The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure===

~~==Overview==~~

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~~Regulators of G-protein signaling (RGS) proteins enhance~~ the intrinsic GTPase activity of G protein alpha (Galpha) subunits and are vital for proper signaling kinetics downstream of G protein-coupled receptors (GPCRs). R7 subfamily RGS proteins specifically and obligately dimerize with the ~~atypical G protein beta5 (Gbeta5) subunit through an internal G protein gamma~~ (~~Ggamma)-subunit-like (GGL) domain~~. ~~Here we present the 1~~.~~95-A crystal structure of the Gbeta5-RGS9 complex~~, ~~which~~ is ~~essential for normal visual and neuronal signal transduction~~. ~~This structure reveals a canonical RGS domain that is functionally integrated within a molecular complex that is poised for integration of multiple steps during G~~-~~protein activation and deactivation.~~

The line below this paragraph, {{ABSTRACT_PUBMED_18204463}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 18204463 is the PubMed ID number.

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==About this Structure==

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[[Category: Rgs domain]]

[[Category: Signaling protein]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 12~~:46:54 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:02:20 2008''

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-[[Image:2pbi.jpg|left|200px]]
+{{Seed}}
+[[Image:2pbi.png|left|200px]]
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 {{STRUCTURE_2pbi|  PDB=2pbi  |  SCENE=  }}
-'''The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure'''
+===The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure===
-==Overview==
+<!--
-Regulators of G-protein signaling (RGS) proteins enhance the intrinsic GTPase activity of G protein alpha (Galpha) subunits and are vital for proper signaling kinetics downstream of G protein-coupled receptors (GPCRs). R7 subfamily RGS proteins specifically and obligately dimerize with the atypical G protein beta5 (Gbeta5) subunit through an internal G protein gamma (Ggamma)-subunit-like (GGL) domain. Here we present the 1.95-A crystal structure of the Gbeta5-RGS9 complex, which is essential for normal visual and neuronal signal transduction. This structure reveals a canonical RGS domain that is functionally integrated within a molecular complex that is poised for integration of multiple steps during G-protein activation and deactivation.
+The line below this paragraph, {{ABSTRACT_PUBMED_18204463}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18204463 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18204463}}
 ==About this Structure==
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 [[Category: Rgs domain]]
 [[Category: Signaling protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 12:46:54 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:02:20 2008''