2vh8: Difference between revisions

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[[Image:2vh8.jpg|left|200px]]
{{Seed}}
[[Image:2vh8.png|left|200px]]


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{{STRUCTURE_2vh8|  PDB=2vh8  |  SCENE=  }}  
{{STRUCTURE_2vh8|  PDB=2vh8  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF SYNAPTIC PROTEIN NEUROLIGIN 4 IN COMPLEX WITH NEUREXIN BETA 1.'''
===CRYSTAL STRUCTURE OF SYNAPTIC PROTEIN NEUROLIGIN 4 IN COMPLEX WITH NEUREXIN BETA 1.===




==Overview==
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The neuroligins are postsynaptic cell adhesion proteins whose associations with presynaptic neurexins participate in synaptogenesis. Mutations in the neuroligin and neurexin genes appear to be associated with autism and mental retardation. The crystal structure of a neuroligin reveals features not found in its catalytically active relatives, such as the fully hydrophobic interface forming the functional neuroligin dimer; the conformations of surface loops surrounding the vestigial active center; the location of determinants that are critical for folding and processing; and the absence of a macromolecular dipole and presence of an electronegative, hydrophilic surface for neurexin binding. The structure of a beta-neurexin-neuroligin complex reveals the precise orientation of the bound neurexin and, despite a limited resolution, provides substantial information on the Ca2+-dependent interactions network involved in trans-synaptic neurexin-neuroligin association. These structures exemplify how an alpha/beta-hydrolase fold varies in surface topography to confer adhesion properties and provide templates for analyzing abnormal processing or recognition events associated with autism.
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{{ABSTRACT_PUBMED_18093521}}


==About this Structure==
==About this Structure==
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[[Category: Membrane]]
[[Category: Membrane]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:48:28 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:06:27 2008''

Revision as of 17:06, 28 July 2008

File:2vh8.png

Template:STRUCTURE 2vh8

CRYSTAL STRUCTURE OF SYNAPTIC PROTEIN NEUROLIGIN 4 IN COMPLEX WITH NEUREXIN BETA 1.

Template:ABSTRACT PUBMED 18093521

About this Structure

2VH8 is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion., Fabrichny IP, Leone P, Sulzenbacher G, Comoletti D, Miller MT, Taylor P, Bourne Y, Marchot P, Neuron. 2007 Dec 20;56(6):979-91. PMID:18093521

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