1oit: Difference between revisions

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[[Image:1oit.jpg|left|200px]]
{{Seed}}
[[Image:1oit.png|left|200px]]


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{{STRUCTURE_1oit|  PDB=1oit  |  SCENE=  }}  
{{STRUCTURE_1oit|  PDB=1oit  |  SCENE=  }}  


'''IMIDAZOPYRIDINES: A POTENT AND SELECTIVE CLASS OF CYCLIN-DEPENDENT KINASE INHIBITORS IDENTIFIED THROUGH STRUCTURE-BASED HYBRIDISATION'''
===IMIDAZOPYRIDINES: A POTENT AND SELECTIVE CLASS OF CYCLIN-DEPENDENT KINASE INHIBITORS IDENTIFIED THROUGH STRUCTURE-BASED HYBRIDISATION===




==Overview==
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High-throughput screening identified the imidazo[1,2-a]pyridine and bisanilinopyrimidine series as inhibitors of the cyclin-dependent kinase CDK4. Comparison of their experimentally-determined binding modes and emerging structure-activity trends led to the development of potent and selective imidazo[1,2-a]pyridine inhibitors for CDK4 and in particular CDK2.
The line below this paragraph, {{ABSTRACT_PUBMED_12941325}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12941325 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12941325}}


==About this Structure==
==About this Structure==
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[[Category: Thomas, A P.]]
[[Category: Thomas, A P.]]
[[Category: Protein kinase]]
[[Category: Protein kinase]]
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