1rhg: Difference between revisions

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[[Image:1rhg.gif|left|200px]]
{{Seed}}
[[Image:1rhg.png|left|200px]]


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{{STRUCTURE_1rhg|  PDB=1rhg  |  SCENE=  }}  
{{STRUCTURE_1rhg|  PDB=1rhg  |  SCENE=  }}  


'''THE STRUCTURE OF GRANULOCYTE-COLONY-STIMULATING FACTOR AND ITS RELATIONSHIP TO THOSE OF OTHER GROWTH FACTORS'''
===THE STRUCTURE OF GRANULOCYTE-COLONY-STIMULATING FACTOR AND ITS RELATIONSHIP TO THOSE OF OTHER GROWTH FACTORS===




==Overview==
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We have determined the three-dimensional structure of recombinant human granulocyte-colony-stimulating factor by x-ray crystallography. Phases were initially obtained at 3.0-A resolution by multiple isomorphous replacement and were refined by solvent flattening and by averaging of the electron density of the three molecules in the asymmetric unit. The current R factor is 21.5% for all data between 6.0- and 2.2-A resolution. The structure is predominantly helical, with 104 of the 175 residues forming a four-alpha-helix bundle. The only other secondary structure is also helical. In the loop between the first two long helices a four-residue 3(10)-helix is immediately followed by a 6-residue alpha-helix. Three residues in the short connection between the second and third bundle helices form almost one turn of left-handed helix. The up-up-down-down connectivity with two long crossover connections has been reported previously for five other proteins, which like granulocyte-colony-stimulating factor are all signaling ligands: growth hormone, granulocyte/macrophage-colony-stimulating factor, interferon beta, interleukin 2, and interleukin 4. Structural similarity among these growth factors occurs despite the absence of similarity in their amino acid sequences. Conservation of this tertiary structure suggests that these different growth factors might all bind to their respective sequence-related receptors in an equivalent manner.
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{{ABSTRACT_PUBMED_7685117}}


==About this Structure==
==About this Structure==
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[[Category: Osslund, T D.]]
[[Category: Osslund, T D.]]
[[Category: Growth factor]]
[[Category: Growth factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:30:11 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:08:40 2008''

Revision as of 17:08, 28 July 2008

File:1rhg.png

Template:STRUCTURE 1rhg

THE STRUCTURE OF GRANULOCYTE-COLONY-STIMULATING FACTOR AND ITS RELATIONSHIP TO THOSE OF OTHER GROWTH FACTORS

Template:ABSTRACT PUBMED 7685117

About this Structure

1RHG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors., Hill CP, Osslund TD, Eisenberg D, Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5167-71. PMID:7685117

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