1o95: Difference between revisions

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[[Image:1o95.jpg|left|200px]]
{{Seed}}
[[Image:1o95.png|left|200px]]


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{{STRUCTURE_1o95|  PDB=1o95  |  SCENE=  }}  
{{STRUCTURE_1o95|  PDB=1o95  |  SCENE=  }}  


'''TERNARY COMPLEX BETWEEN TRIMETHYLAMINE DEHYDROGENASE AND ELECTRON TRANSFERRING FLAVOPROTEIN'''
===TERNARY COMPLEX BETWEEN TRIMETHYLAMINE DEHYDROGENASE AND ELECTRON TRANSFERRING FLAVOPROTEIN===




==Overview==
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Here we report the crystal structures of a ternary electron transfer complex showing extensive motion at the protein interface. This physiological complex comprises the iron-sulfur flavoprotein trimethylamine dehydrogenase and electron transferring flavoprotein (ETF) from Methylophilus methylotrophus. In addition, we report the crystal structure of free ETF. In the complex, electron density for the FAD domain of ETF is absent, indicating high mobility. Positions for the FAD domain are revealed by molecular dynamics simulation, consistent with crystal structures and kinetic data. A dual interaction of ETF with trimethylamine dehydrogenase provides for dynamical motion at the protein interface: one site acts as an anchor, thereby allowing the other site to sample a large range of interactions, some compatible with rapid electron transfer. This study establishes the role of conformational sampling in multi-domain redox systems, providing insight into electron transfer between ETFs and structurally distinct redox partners.
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{{ABSTRACT_PUBMED_12567183}}


==About this Structure==
==About this Structure==
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[[Category: Electron transfer]]
[[Category: Electron transfer]]
[[Category: Protein complex]]
[[Category: Protein complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:32:39 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:17:06 2008''

Revision as of 17:17, 28 July 2008

File:1o95.png

Template:STRUCTURE 1o95

TERNARY COMPLEX BETWEEN TRIMETHYLAMINE DEHYDROGENASE AND ELECTRON TRANSFERRING FLAVOPROTEIN

Template:ABSTRACT PUBMED 12567183

About this Structure

1O95 is a Protein complex structure of sequences from Methylophilus methylotrophus. Full crystallographic information is available from OCA.

Reference

Extensive conformational sampling in a ternary electron transfer complex., Leys D, Basran J, Talfournier F, Sutcliffe MJ, Scrutton NS, Nat Struct Biol. 2003 Mar;10(3):219-25. PMID:12567183

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