2i2p: Difference between revisions

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[[Image:2i2p.gif|left|200px]]
{{Seed}}
[[Image:2i2p.png|left|200px]]


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{{STRUCTURE_2i2p|  PDB=2i2p  |  SCENE=  }}  
{{STRUCTURE_2i2p|  PDB=2i2p  |  SCENE=  }}  


'''Crystal Structure of Ribosome with messenger RNA and the Anticodon stem-loop of P-site tRNA. This file contains the 30s subunit of one 70s ribosome. The entire crystal structure contains two 70s ribosomes and is described in remark 400.'''
===Crystal Structure of Ribosome with messenger RNA and the Anticodon stem-loop of P-site tRNA. This file contains the 30s subunit of one 70s ribosome. The entire crystal structure contains two 70s ribosomes and is described in remark 400.===




==Overview==
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Protein synthesis requires the accurate positioning of mRNA and tRNA in the peptidyl-tRNA site of the ribosome. Here we describe x-ray crystal structures of the intact bacterial ribosome from Escherichia coli in a complex with mRNA and the anticodon stem-loop of P-site tRNA. At 3.5-A resolution, these structures reveal rearrangements in the intact ribosome that clamp P-site tRNA and mRNA on the small ribosomal subunit. Binding of the anticodon stem-loop of P-site tRNA to the ribosome is sufficient to lock the head of the small ribosomal subunit in a single conformation, thereby preventing movement of mRNA and tRNA before mRNA decoding.
The line below this paragraph, {{ABSTRACT_PUBMED_17038497}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17038497}}


==About this Structure==
==About this Structure==
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[[Category: 30s ribosomal subunit]]
[[Category: 30s ribosomal subunit]]
[[Category: Protein-nucleic acid complex]]
[[Category: Protein-nucleic acid complex]]
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