1qas: Difference between revisions

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[[Image:1qas.gif|left|200px]]
{{Seed}}
[[Image:1qas.png|left|200px]]


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{{STRUCTURE_1qas|  PDB=1qas  |  SCENE=  }}  
{{STRUCTURE_1qas|  PDB=1qas  |  SCENE=  }}  


'''1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1'''
===1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1===




==Overview==
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The structure of the PH-domain truncated core of rat phosphoinositide-specific phospholipase C-delta 1 has been determined at 2.4 A resolution and compared to the structure previously determined in a different crystal form. The stereochemical relationship between the EF, catalytic, and C2 domains is essentially identical. The Ca2+ analogue Sm3+ binds at two sites between the jaws of the C2 domain. Sm3+ binding ejects three lysine residues which bridge the gap between the jaws and occupy the Ca2+ site in the apoenzyme, triggering a conformational change in the jaws. The distal sections of the C2 jaws move apart, opening the mouth by 9 A and creating a gap large enough to bind a phospholipid headgroup.
The line below this paragraph, {{ABSTRACT_PUBMED_8784353}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_8784353}}


==About this Structure==
==About this Structure==
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[[Category: Lipid degradation]]
[[Category: Lipid degradation]]
[[Category: Transducer]]
[[Category: Transducer]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:04:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:24:38 2008''

Revision as of 17:24, 28 July 2008

File:1qas.png

Template:STRUCTURE 1qas

1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1

Template:ABSTRACT PUBMED 8784353

About this Structure

1QAS is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

C2 domain conformational changes in phospholipase C-delta 1., Grobler JA, Essen LO, Williams RL, Hurley JH, Nat Struct Biol. 1996 Sep;3(9):788-95. PMID:8784353

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