2uus: Difference between revisions

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[[Image:2uus.~~jpg~~|left|200px]]

[[Image:2uus.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF THE RAT FGF1-SUCROSE OCTASULFATE (SOS) COMPLEX.~~'''~~

===CRYSTAL STRUCTURE OF THE RAT FGF1-SUCROSE OCTASULFATE (SOS) COMPLEX.===

~~==Overview==~~

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~~Fibroblast growth factors (FGFs) constitute a family of at least 23 structurally related heparin-binding proteins that are involved in regulation of cell growth~~, ~~survival~~, ~~differentiation and migration. Sucrose octasulfate (SOS), a chemical analogue of heparin, has been demonstrated~~ to ~~activate FGF signalling pathways. The structure of rat FGF1 crystallized in~~ the ~~presence of SOS has been determined~~ at 2.~~2 A resolution~~. ~~SOS-mediated dimerization of FGF1 was observed~~, ~~which was further supported by gel-filtration experiments~~. ~~The major contributors to the sulfate~~-binding sites in rat FGF1 are Lys113, Lys118, Arg122 and Lys128. An arginine at position 116 is a consensus residue in mammalian FGF molecules; however, it is a serine in rat FGF1. This difference may be important for SOS-~~mediated FGF1 dimerization in rat.~~

The line below this paragraph, {{ABSTRACT_PUBMED_18540049}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 18540049 is the PubMed ID number.

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==About this Structure==

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[[Category: Mitogen]]

[[Category: Sucrose octasulfate]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jun 18 12~~:17:34 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:31:43 2008''

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-[[Image:2uus.jpg|left|200px]]
+{{Seed}}
+[[Image:2uus.png|left|200px]]
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 {{STRUCTURE_2uus|  PDB=2uus  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF THE RAT FGF1-SUCROSE OCTASULFATE (SOS) COMPLEX.'''
+===CRYSTAL STRUCTURE OF THE RAT FGF1-SUCROSE OCTASULFATE (SOS) COMPLEX.===
-==Overview==
+<!--
-Fibroblast growth factors (FGFs) constitute a family of at least 23 structurally related heparin-binding proteins that are involved in regulation of cell growth, survival, differentiation and migration. Sucrose octasulfate (SOS), a chemical analogue of heparin, has been demonstrated to activate FGF signalling pathways. The structure of rat FGF1 crystallized in the presence of SOS has been determined at 2.2 A resolution. SOS-mediated dimerization of FGF1 was observed, which was further supported by gel-filtration experiments. The major contributors to the sulfate-binding sites in rat FGF1 are Lys113, Lys118, Arg122 and Lys128. An arginine at position 116 is a consensus residue in mammalian FGF molecules; however, it is a serine in rat FGF1. This difference may be important for SOS-mediated FGF1 dimerization in rat.
+The line below this paragraph, {{ABSTRACT_PUBMED_18540049}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18540049 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18540049}}
 ==About this Structure==
@@ Line 37: / Line 41: @@
 [[Category: Mitogen]]
 [[Category: Sucrose octasulfate]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:17:34 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:31:43 2008''