1npu: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
Line 1: Line 1:
[[Image:1npu.gif|left|200px]]
{{Seed}}
[[Image:1npu.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1npu|  PDB=1npu  |  SCENE=  }}  
{{STRUCTURE_1npu|  PDB=1npu  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1'''
===CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1===




==Overview==
<!--
PD-1, a member of the CD28/CTLA-4/ICOS costimulatory receptor family, delivers negative signals that have profound effects on T and B cell immunity. The 2.0 A crystal structure of the extracellular domain of murine PD-1 reveals an Ig V-type topology with overall similarity to the CTLA-4 monomer; however, there are notable differences in regions relevant to function. Our structural and biophysical data show that PD-1 is monomeric both in solution as well as on cell surface, in contrast to CTLA-4 and other family members that are all disulfide-linked homodimers. Furthermore, our structure-based mutagenesis studies identify the ligand binding surface of PD-1, which displays significant differences compared to those present in the other members of the family.
The line below this paragraph, {{ABSTRACT_PUBMED_15030777}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15030777 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_15030777}}


==About this Structure==
==About this Structure==
Line 37: Line 41:
[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:50:06 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:34:01 2008''
Retrieved from "https://proteopedia.org/1npu"