1r44: Difference between revisions

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[[Image:1r44.~~jpg~~|left|200px]]

[[Image:1r44.png|left|200px]]

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~~'''~~Crystal Structure of VanX~~'''~~

===Crystal Structure of VanX===

~~==Overview==~~

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~~VanX is a zinc~~-~~dependent D~~-alanyl-D-alanine dipeptidase that is a critical component in a system that mediates transposon-based vancomycin resistance in enterococci. It is also a key drug target in circumventing clinical vancomycin resistance. The structure of VanX from E. faecium has been solved by X-ray crystallography and reveals a Zn(2+)-dipeptidase with a unique overall fold and a well-defined active site confined within a cavity of limited size. The crystal structures of VanX, the ~~VanX:D-alanyl-D-alanine complex,~~ the ~~VanX~~:~~D-alanine complex~~, and VanX in complex with phosphonate and phosphinate transition-state analog inhibitors, are also presented at high resolution. Structural homology searches of known structures revealed that the fold of VanX is ~~similar to those of two proteins:~~ the N-~~terminal fragment of murine Sonic hedgehog and the Zn(2+)~~-~~dependent N-acyl-D-alanyl-D-alanine carboxypeptidase of S. albus G.~~

The line below this paragraph, {{ABSTRACT_PUBMED_9702193}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9702193 is the PubMed ID number.

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==About this Structure==

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[[Category: E faecium]]

[[Category: Vanx]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 07~~:02:55 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:34:20 2008''

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-[[Image:1r44.jpg|left|200px]]
+{{Seed}}
+[[Image:1r44.png|left|200px]]
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 {{STRUCTURE_1r44|  PDB=1r44  |  SCENE=  }}
-'''Crystal Structure of VanX'''
+===Crystal Structure of VanX===
-==Overview==
+<!--
-VanX is a zinc-dependent D-alanyl-D-alanine dipeptidase that is a critical component in a system that mediates transposon-based vancomycin resistance in enterococci. It is also a key drug target in circumventing clinical vancomycin resistance. The structure of VanX from E. faecium has been solved by X-ray crystallography and reveals a Zn(2+)-dipeptidase with a unique overall fold and a well-defined active site confined within a cavity of limited size. The crystal structures of VanX, the VanX:D-alanyl-D-alanine complex, the VanX:D-alanine complex, and VanX in complex with phosphonate and phosphinate transition-state analog inhibitors, are also presented at high resolution. Structural homology searches of known structures revealed that the fold of VanX is similar to those of two proteins: the N-terminal fragment of murine Sonic hedgehog and the Zn(2+)-dependent N-acyl-D-alanyl-D-alanine carboxypeptidase of S. albus G.
+The line below this paragraph, {{ABSTRACT_PUBMED_9702193}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9702193 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9702193}}
 ==About this Structure==
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 [[Category: E faecium]]
 [[Category: Vanx]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:02:55 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:34:20 2008''