2h4k: Difference between revisions

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[[Image:2h4k.gif|left|200px]]
{{Seed}}
[[Image:2h4k.png|left|200px]]


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{{STRUCTURE_2h4k|  PDB=2h4k  |  SCENE=  }}  
{{STRUCTURE_2h4k|  PDB=2h4k  |  SCENE=  }}  


'''Crystal structure of PTP1B with a monocyclic thiophene inhibitor'''
===Crystal structure of PTP1B with a monocyclic thiophene inhibitor===




==Overview==
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A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency against PTP1B.
The line below this paragraph, {{ABSTRACT_PUBMED_16806920}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16806920}}


==About this Structure==
==About this Structure==
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[[Category: Xu, W.]]
[[Category: Xu, W.]]
[[Category: Protein-drug complex structure]]
[[Category: Protein-drug complex structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:51:33 2008''
 
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