2f44: Difference between revisions

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[[Image:2f44.gif|left|200px]]
{{Seed}}
[[Image:2f44.png|left|200px]]


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{{STRUCTURE_2f44|  PDB=2f44  |  SCENE=  }}  
{{STRUCTURE_2f44|  PDB=2f44  |  SCENE=  }}  


'''Crystal Structure of the Zinc-bound Shank SAM domain'''
===Crystal Structure of the Zinc-bound Shank SAM domain===




==Overview==
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The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytoskeletal matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side by side. Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex.
The line below this paragraph, {{ABSTRACT_PUBMED_16439662}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16439662 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16439662}}


==About this Structure==
==About this Structure==
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[[Category: Shank]]
[[Category: Shank]]
[[Category: Zinc]]
[[Category: Zinc]]
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