2v60: Difference between revisions

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[[Image:2v60.~~gif~~|left|200px]]

[[Image:2v60.png|left|200px]]

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~~'''~~STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR 7-(3-CHLOROBENZYLOXY)-4-CARBOXALDEHYDE-COUMARIN~~'''~~

===STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR 7-(3-CHLOROBENZYLOXY)-4-CARBOXALDEHYDE-COUMARIN===

~~==Overview==~~

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~~Structures of human monoamine oxidase B (MAO B) in complex with safinamide and two coumarin derivatives~~, ~~all sharing a common benzyloxy substituent~~, ~~were determined by X-ray crystallography. These compounds competitively inhibit MAO B with Ki values in~~ the 0.~~1-0~~.~~5 microM range that are 30-700-fold lower than those observed with MAO A. The inhibitors bind noncovalently to MAO B~~, ~~occupying both~~ the ~~entrance and the substrate cavities and showing a similarly oriented benzyloxy substituent~~.

The line below this paragraph, {{ABSTRACT_PUBMED_17915852}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17915852 is the PubMed ID number.

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==About this Structure==

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[[Category: Safinamide]]

[[Category: Transmembrane]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 18~~:14:31 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:03:37 2008''

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-[[Image:2v60.gif|left|200px]]
+{{Seed}}
+[[Image:2v60.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2v60|  PDB=2v60  |  SCENE=  }}
-'''STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR 7-(3-CHLOROBENZYLOXY)-4-CARBOXALDEHYDE-COUMARIN'''
+===STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR 7-(3-CHLOROBENZYLOXY)-4-CARBOXALDEHYDE-COUMARIN===
-==Overview==
+<!--
-Structures of human monoamine oxidase B (MAO B) in complex with safinamide and two coumarin derivatives, all sharing a common benzyloxy substituent, were determined by X-ray crystallography. These compounds competitively inhibit MAO B with Ki values in the 0.1-0.5 microM range that are 30-700-fold lower than those observed with MAO A. The inhibitors bind noncovalently to MAO B, occupying both the entrance and the substrate cavities and showing a similarly oriented benzyloxy substituent.
+The line below this paragraph, {{ABSTRACT_PUBMED_17915852}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17915852 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17915852}}
 ==About this Structure==
@@ Line 41: / Line 45: @@
 [[Category: Safinamide]]
 [[Category: Transmembrane]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:14:31 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:03:37 2008''