1pmc: Difference between revisions

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[[Image:1pmc.gif|left|200px]]
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[[Image:1pmc.png|left|200px]]


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{{STRUCTURE_1pmc|  PDB=1pmc  |  SCENE=  }}  
{{STRUCTURE_1pmc|  PDB=1pmc  |  SCENE=  }}  


'''PROTEINASE INHIBITOR PMP-C (NMR, 36 STRUCTURES)'''
===PROTEINASE INHIBITOR PMP-C (NMR, 36 STRUCTURES)===




==Overview==
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The solution structure and the disulfide pairings of a 36-residue proteinase inhibitor isolated from the insect Locusta migratoria have been determined using NMR spectroscopy and simulated annealing calculations. The peptide, termed PMP-C, was previously shown to inhibit bovine alpha-chymotrypsin as well as human leukocyte elastase, and was also found to block high-voltage-activated Ca2+ currents in rat sensory neurones. PMP-C has a prolate ellipsoid shape and adopts a tertiary fold hitherto unobserved in the large group of small "canonical" proteinase inhibitors. The over-all fold consists mainly of three strands arranged in a right-handed twisted, antiparallel, beta-sheet that demarcates a cavity, together with a linear amino-terminal segment oriented almost perpendicular to the three strands of the beta-sheet. Inside the cavity a phenyl ring constitutes the centre of a hydrophobic core. The proteinase binding loop is located in the carboxy-terminal part of the molecule, between two cysteine residues involved in disulfide bridges. Its conformation resembles that found in other small canonical proteinase inhibitors. A comparison of PMP-C structure with the recently published solution structure of the related peptide PMP-D2 shows that the most significant differences are complementary changes involved in the stabilization of similar folds. This comparison led us to review the structure of PMP-D2 and to identify two salt bridges in PMP-D2.
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{{ABSTRACT_PUBMED_8613985}}


==About this Structure==
==About this Structure==
1PMC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Locusta_migratoria Locusta migratoria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PMC OCA].  
1PMC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Locusta_migratoria Locusta migratoria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PMC OCA].  


==Reference==
==Reference==
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[[Category: Mer, G.]]
[[Category: Mer, G.]]
[[Category: Calcium channel blocker]]
[[Category: Calcium channel blocker]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:14:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:10:05 2008''

Revision as of 18:10, 28 July 2008

File:1pmc.png

Template:STRUCTURE 1pmc

PROTEINASE INHIBITOR PMP-C (NMR, 36 STRUCTURES)

Template:ABSTRACT PUBMED 8613985

About this Structure

1PMC is a Single protein structure of sequence from Locusta migratoria. Full experimental information is available from OCA.

Reference

Solution structure of PMP-C: a new fold in the group of small serine proteinase inhibitors., Mer G, Hietter H, Kellenberger C, Renatus M, Luu B, Lefevre JF, J Mol Biol. 1996 Apr 26;258(1):158-71. PMID:8613985

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