1ogp: Difference between revisions

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[[Image:1ogp.~~jpg~~|left|200px]]

[[Image:1ogp.png|left|200px]]

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~~'''~~THE CRYSTAL STRUCTURE OF PLANT SULFITE OXIDASE PROVIDES INSIGHT INTO SULFITE OXIDATION IN PLANTS AND ANIMALS~~'''~~

===THE CRYSTAL STRUCTURE OF PLANT SULFITE OXIDASE PROVIDES INSIGHT INTO SULFITE OXIDATION IN PLANTS AND ANIMALS===

~~==Overview==~~

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The molybdenum cofactor (Moco) containing sulfite oxidase (SO) from Arabidopsis thaliana has recently been identified and biochemically characterized. The enzyme is found in peroxisomes and believed to detoxify excess sulfite that is produced during sulfur assimilation, ~~or due to air pollution. Plant SO (PSO) is homodimeric and homologous to animal SO~~, ~~but contains only a single Moco domain without an additional redox center. Here, we present~~ the ~~first crystal structure of a plant Moco enzyme,~~ the ~~apo-state of Arabidopsis SO~~ at 2.~~6 A resolution~~. ~~The overall fold and coordination of the Moco are similar to chicken SO (CSO~~)~~. Comparisons of conserved surface residues and~~ the charge distribution in PSO and CSO reveal major differences near the entrance to both active sites reflecting different electron acceptors. Arg374 has been identified as an important substrate binding residue due to its conformational change when compared to the sulfate bound structure of CSO.

The line below this paragraph, {{ABSTRACT_PUBMED_14527393}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 14527393 is the PubMed ID number.

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==About this Structure==

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[[Category: Peroxisome]]

[[Category: Plant sulfite oxidase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 03~~:49:23 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:15:19 2008''

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-[[Image:1ogp.jpg|left|200px]]
+{{Seed}}
+[[Image:1ogp.png|left|200px]]
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 {{STRUCTURE_1ogp|  PDB=1ogp  |  SCENE=  }}
-'''THE CRYSTAL STRUCTURE OF PLANT SULFITE OXIDASE PROVIDES INSIGHT INTO SULFITE OXIDATION IN PLANTS AND ANIMALS'''
+===THE CRYSTAL STRUCTURE OF PLANT SULFITE OXIDASE PROVIDES INSIGHT INTO SULFITE OXIDATION IN PLANTS AND ANIMALS===
-==Overview==
+<!--
-The molybdenum cofactor (Moco) containing sulfite oxidase (SO) from Arabidopsis thaliana has recently been identified and biochemically characterized. The enzyme is found in peroxisomes and believed to detoxify excess sulfite that is produced during sulfur assimilation, or due to air pollution. Plant SO (PSO) is homodimeric and homologous to animal SO, but contains only a single Moco domain without an additional redox center. Here, we present the first crystal structure of a plant Moco enzyme, the apo-state of Arabidopsis SO at 2.6 A resolution. The overall fold and coordination of the Moco are similar to chicken SO (CSO). Comparisons of conserved surface residues and the charge distribution in PSO and CSO reveal major differences near the entrance to both active sites reflecting different electron acceptors. Arg374 has been identified as an important substrate binding residue due to its conformational change when compared to the sulfate bound structure of CSO.
+The line below this paragraph, {{ABSTRACT_PUBMED_14527393}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14527393 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14527393}}
 ==About this Structure==
@@ Line 34: / Line 38: @@
 [[Category: Peroxisome]]
 [[Category: Plant sulfite oxidase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:49:23 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:15:19 2008''