1no8: Difference between revisions

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[[Image:1no8.jpg|left|200px]]
{{Seed}}
[[Image:1no8.png|left|200px]]


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{{STRUCTURE_1no8|  PDB=1no8  |  SCENE=  }}  
{{STRUCTURE_1no8|  PDB=1no8  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE NUCLEAR FACTOR ALY RBD DOMAIN'''
===SOLUTION STRUCTURE OF THE NUCLEAR FACTOR ALY RBD DOMAIN===




==Overview==
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ALY is a ubiquitously expressed nuclear protein which interacts with proteins such as TAP that are involved in export of mRNA from the nucleus to the cytoplasm, as well as with proteins that bind the T cell receptor alpha gene enhancer. ALY has also been shown to bind mRNA and to co-localize in the nucleus with components of a multiprotein postsplicing complex that is deposited 20-24 nucleotides upstream of exon-exon junctions. ALY has a conserved RNA binding domain (RBD) flanked by Gly-Arg rich N-terminal and C-terminal sequences. We determined the solution structure of the RBD homology region in ALY by nuclear magnetic resonance methods. The RBD motif in ALY has a characteristic beta(1)alpha(1)beta(2)-beta(3)alpha(2)beta(4) fold, consisting of a beta sheet composed of four antiparallel beta strands and two alpha helices that pack on one face of the beta sheet. As in other RBD structures, the beta sheet has an exposed face with hydrophobic and charged residues that could modulate interactions with other molecules. The loop that connects beta strands 2 and 3 is in intermediate motion in the NMR time scale, which is also characteristic of other RBDs. This loop presents side chains close to the exposed surface of the beta sheet and is a primary candidate site for intermolecular interactions. The structure of the conserved RBD of ALY provides insight into the nature of interactions involving this multifunctional protein.
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{{ABSTRACT_PUBMED_12809490}}


==About this Structure==
==About this Structure==
1NO8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NO8 OCA].  
1NO8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NO8 OCA].  


==Reference==
==Reference==
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[[Category: Rbd]]
[[Category: Rbd]]
[[Category: Ref1-i]]
[[Category: Ref1-i]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:46:22 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:26:39 2008''

Revision as of 18:26, 28 July 2008

File:1no8.png

Template:STRUCTURE 1no8

SOLUTION STRUCTURE OF THE NUCLEAR FACTOR ALY RBD DOMAIN

Template:ABSTRACT PUBMED 12809490

About this Structure

1NO8 is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Structure of the nuclear factor ALY: insights into post-transcriptional regulatory and mRNA nuclear export processes., Perez-Alvarado GC, Martinez-Yamout M, Allen MM, Grosschedl R, Dyson HJ, Wright PE, Biochemistry. 2003 Jun 24;42(24):7348-57. PMID:12809490

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