3c2h: Difference between revisions

Line 1:

[[Image:3c2h.~~jpg~~|left|200px]]

[[Image:3c2h.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Crystal Structure of SYS-1 at 2.6A resolution~~'''~~

===Crystal Structure of SYS-1 at 2.6A resolution===

~~==Overview==~~

<!--

~~C. elegans SYS~~-~~1 has key functional characteristics of a canonical beta~~-~~catenin~~, ~~but no significant sequence similarity. Here~~, ~~we report~~ the ~~SYS-1 crystal structure, both~~ on ~~its own and in a complex with POP-1, the C. elegans TCF homolog. The two structures possess signature features of canonical beta-catenin and the beta-catenin~~/~~TCF complex that could not be predicted by sequence. Most importantly, SYS-1 bears 12 armadillo repeats and the SYS-1~~/~~POP-1 interface is anchored by a conserved salt-bridge, the "charged button." We also modeled structures for three other C~~. ~~elegans beta-catenins to predict the molecular basis of their distinct binding properties~~. ~~Finally~~, ~~we generated a phylogenetic tree, using the region of highest structural similarity between SYS-1 and beta-catenin, and found that SYS-1 clusters robustly within~~ the ~~beta-catenin clade~~. ~~We conclude that the SYS-1 protein belongs to the beta~~-~~catenin family and suggest that additional divergent beta~~-~~catenins await discovery.~~

The line below this paragraph, {{ABSTRACT_PUBMED_18477457}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 18477457 is the PubMed ID number.

-->

==About this Structure==

Line 32:

Line 36:

[[Category: Sys-1]]

[[Category: Wnt]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu May 22~~ 21:54:11 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:31:36 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:3c2h.jpg|left|200px]]
+{{Seed}}
+[[Image:3c2h.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_3c2h|  PDB=3c2h  |  SCENE=  }}
-'''Crystal Structure of SYS-1 at 2.6A resolution'''
+===Crystal Structure of SYS-1 at 2.6A resolution===
-==Overview==
+<!--
-C. elegans SYS-1 has key functional characteristics of a canonical beta-catenin, but no significant sequence similarity. Here, we report the SYS-1 crystal structure, both on its own and in a complex with POP-1, the C. elegans TCF homolog. The two structures possess signature features of canonical beta-catenin and the beta-catenin/TCF complex that could not be predicted by sequence. Most importantly, SYS-1 bears 12 armadillo repeats and the SYS-1/POP-1 interface is anchored by a conserved salt-bridge, the "charged button." We also modeled structures for three other C. elegans beta-catenins to predict the molecular basis of their distinct binding properties. Finally, we generated a phylogenetic tree, using the region of highest structural similarity between SYS-1 and beta-catenin, and found that SYS-1 clusters robustly within the beta-catenin clade. We conclude that the SYS-1 protein belongs to the beta-catenin family and suggest that additional divergent beta-catenins await discovery.
+The line below this paragraph, {{ABSTRACT_PUBMED_18477457}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18477457 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18477457}}
 ==About this Structure==
@@ Line 32: / Line 36: @@
 [[Category: Sys-1]]
 [[Category: Wnt]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 21:54:11 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:31:36 2008''