2gum: Difference between revisions

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[[Image:2gum.~~gif~~|left|200px]]

[[Image:2gum.png|left|200px]]

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~~'''~~Crystal structure of the extracellular domain of glycoprotein B from Herpes Simplex Virus type I~~'''~~

===Crystal structure of the extracellular domain of glycoprotein B from Herpes Simplex Virus type I===

~~==Overview==~~

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~~Glycoprotein B (gB) is~~ the ~~most conserved component of~~ the ~~complex cell-entry machinery of herpes viruses~~. ~~A crystal structure of the gB ectodomain from herpes simplex virus type 1 reveals a multidomain trimer with unexpected homology to glycoprotein G from vesicular stomatitis virus (VSV G~~)~~. An alpha-helical coiled-coil core relates gB to class I viral membrane fusion glycoproteins; two extended beta hairpins with hydrophobic tips~~, ~~homologous to fusion peptides in VSV G, relate gB to class II fusion proteins~~. ~~Members of both classes accomplish fusion through a large~~-~~scale conformational change, triggered by a signal from a receptor~~-~~binding component. The domain connectivity within a gB monomer would permit such a rearrangement, including long-range translocations linked to viral and cellular membranes.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16840698}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16840698 is the PubMed ID number.

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==About this Structure==

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[[Category: Membrane fusion]]

[[Category: Virus]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 05~~:33:29 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:34:11 2008''

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-[[Image:2gum.gif|left|200px]]
+{{Seed}}
+[[Image:2gum.png|left|200px]]
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 {{STRUCTURE_2gum|  PDB=2gum  |  SCENE=  }}
-'''Crystal structure of the extracellular domain of glycoprotein B from Herpes Simplex Virus type I'''
+===Crystal structure of the extracellular domain of glycoprotein B from Herpes Simplex Virus type I===
-==Overview==
+<!--
-Glycoprotein B (gB) is the most conserved component of the complex cell-entry machinery of herpes viruses. A crystal structure of the gB ectodomain from herpes simplex virus type 1 reveals a multidomain trimer with unexpected homology to glycoprotein G from vesicular stomatitis virus (VSV G). An alpha-helical coiled-coil core relates gB to class I viral membrane fusion glycoproteins; two extended beta hairpins with hydrophobic tips, homologous to fusion peptides in VSV G, relate gB to class II fusion proteins. Members of both classes accomplish fusion through a large-scale conformational change, triggered by a signal from a receptor-binding component. The domain connectivity within a gB monomer would permit such a rearrangement, including long-range translocations linked to viral and cellular membranes.
+The line below this paragraph, {{ABSTRACT_PUBMED_16840698}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16840698 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16840698}}
 ==About this Structure==
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 [[Category: Membrane fusion]]
 [[Category: Virus]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:33:29 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:34:11 2008''