1t7s: Difference between revisions

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[[Image:1t7s.gif|left|200px]]
{{Seed}}
[[Image:1t7s.png|left|200px]]


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{{STRUCTURE_1t7s|  PDB=1t7s  |  SCENE=  }}  
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'''Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein'''
===Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein===




==Overview==
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Binding of the BAG domain to the eukaryotic chaperone heat-shock protein (Hsp70) promotes ATP-dependent release of the protein substrate from Hsp70. Although the murine and human BAG domains have been shown to form an antiparallel three-helix bundle, the Caenorhabditis elegans BAG domain is formed by two antiparallel helices, while the third helix is extended away and stabilized by crystal-packing interactions. A small beta-sheet between helices 2 and 3 interferes with formation of the intramolecular three-helix bundle. However, intermolecular three-helix bundles are observed throughout the crystal packing and suggest that stable functional dimers and tetramers can be formed in solution. The structure may represent a new folding type of the BAG domain.
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{{ABSTRACT_PUBMED_15333932}}


==About this Structure==
==About this Structure==
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[[Category: Southeast collaboratory for structural genomic]]
[[Category: Southeast collaboratory for structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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