2pfi: Difference between revisions

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[[Image:2pfi.jpg|left|200px]]
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{{STRUCTURE_2pfi|  PDB=2pfi  |  SCENE=  }}  
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'''Crystal structure of the cytoplasmic domain of the human chloride channel ClC-Ka'''
===Crystal structure of the cytoplasmic domain of the human chloride channel ClC-Ka===




==Overview==
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The cytoplasmic domains of ClC chloride channels and transporters are ubiquitously found in eukaryotic family members and have been suggested to be involved in the regulation of ion transport. All cytoplasmic ClC domains share a conserved scaffold that contains a pair of CBS motifs. Here we describe the structure of the cytoplasmic component of the human chloride channel ClC-Ka at 1.6 A resolution. The structure reveals a dimeric organization of the domain that is unusual for CBS motif containing proteins. Using a biochemical approach combining mutagenesis, crosslinking, and analytical ultracentrifugation, we demonstrate that the interaction interface is preserved in solution and that the distantly related channel ClC-0 likely exhibits a similar structural organization. Our results reveal a conserved interaction interface that relates the cytoplasmic domains of ClC proteins and establish a structural relationship that is likely general for this important family of transport proteins.
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==Disease==
==Disease==
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[[Category: Dutzler, R.]]
[[Category: Dutzler, R.]]
[[Category: Markovic, S.]]
[[Category: Markovic, S.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 13:00:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:55:07 2008''

Revision as of 18:55, 28 July 2008

File:2pfi.png

Template:STRUCTURE 2pfi

Crystal structure of the cytoplasmic domain of the human chloride channel ClC-Ka

Template:ABSTRACT PUBMED 17562318

Disease

Known disease associated with this structure: Bartter syndrome, type 4, digenic OMIM:[602024]

About this Structure

2PFI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of the cytoplasmic domain of the chloride channel ClC-Ka reveals a conserved interaction interface., Markovic S, Dutzler R, Structure. 2007 Jun;15(6):715-25. PMID:17562318

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