2hxw: Difference between revisions

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[[Image:2hxw.jpg|left|200px]]
{{Seed}}
[[Image:2hxw.png|left|200px]]


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{{STRUCTURE_2hxw|  PDB=2hxw  |  SCENE=  }}  
{{STRUCTURE_2hxw|  PDB=2hxw  |  SCENE=  }}  


'''Crystal Structure of Peb3 from Campylobacter jejuni'''
===Crystal Structure of Peb3 from Campylobacter jejuni===




==Overview==
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Campylobacter jejuni is unusual among bacteria in possessing a eukaryotic-like system for N-linked protein glycosylation at Asn residues in sequons of the type Asp/Glu-Xaa-Asn-Xaa-Ser/Thr. However, little is known about the structural context of the glycosylated sequons, limiting the design of novel recombinant glycoproteins. To obtain more information on sequon structure, we have determined the crystal structure of the PEB3 (Cj0289c) dimer. PEB3 has the class II periplasmic-binding protein fold, with each monomer having two domains with a ligand-binding site containing citrate located between them, and overall resembles molybdate- and sulfate-binding proteins. The sequon around Asn90 is located within a surface-exposed loop joining two structural elements. The three key residues are well exposed on the surface; hence, they may be accessible to the PglB oligosaccharyltransferase in the folded state.
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{{ABSTRACT_PUBMED_17456748}}


==About this Structure==
==About this Structure==
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[[Category: Periplasmic binding protein]]
[[Category: Periplasmic binding protein]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:50:52 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:39:47 2008''

Revision as of 19:40, 28 July 2008

File:2hxw.png

Template:STRUCTURE 2hxw

Crystal Structure of Peb3 from Campylobacter jejuni

Template:ABSTRACT PUBMED 17456748

About this Structure

2HXW is a Single protein structure of sequence from Campylobacter jejuni. Full crystallographic information is available from OCA.

Reference

Structural context for protein N-glycosylation in bacteria: The structure of PEB3, an adhesin from Campylobacter jejuni., Rangarajan ES, Bhatia S, Watson DC, Munger C, Cygler M, Matte A, Young NM, Protein Sci. 2007 May;16(5):990-5. PMID:17456748

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