2h4g: Difference between revisions

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[[Image:2h4g.gif|left|200px]]
{{Seed}}
[[Image:2h4g.png|left|200px]]


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{{STRUCTURE_2h4g|  PDB=2h4g  |  SCENE=  }}  
{{STRUCTURE_2h4g|  PDB=2h4g  |  SCENE=  }}  


'''Crystal structure of PTP1B with monocyclic thiophene inhibitor'''
===Crystal structure of PTP1B with monocyclic thiophene inhibitor===




==Overview==
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A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency against PTP1B.
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{{ABSTRACT_PUBMED_16806920}}


==About this Structure==
==About this Structure==
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[[Category: Xu, W.]]
[[Category: Xu, W.]]
[[Category: Protein-drug complex]]
[[Category: Protein-drug complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:51:22 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:52:17 2008''

Revision as of 19:52, 28 July 2008

File:2h4g.png

Template:STRUCTURE 2h4g

Crystal structure of PTP1B with monocyclic thiophene inhibitor

Template:ABSTRACT PUBMED 16806920

About this Structure

2H4G is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48., Wan ZK, Lee J, Xu W, Erbe DV, Joseph-McCarthy D, Follows BC, Zhang YL, Bioorg Med Chem Lett. 2006 Sep 15;16(18):4941-5. Epub 2006 Jun 27. PMID:16806920

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