1vqc: Difference between revisions

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[[Image:1vqc.~~jpg~~|left|200px]]

[[Image:1vqc.png|left|200px]]

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~~'''~~GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY PHE 47 (V35I, I47F)~~'''~~

===GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY PHE 47 (V35I, I47F)===

~~==Overview==~~

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The ~~problem of rationally engineering protein molecules can be simplified where effects of mutations~~ on ~~protein function are additive~~. ~~Crystal structures of single and double mutants in~~ the hydrophobic core of gene V protein indicate that structural and functional effects of core mutations are additive when the regions structurally influenced by the mutations do not substantially overlap. These regions of influence can provide a simple basis for identifying sets of mutations that will show additive effects.

The line below this paragraph, {{ABSTRACT_PUBMED_8855252}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8855252 is the PubMed ID number.

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==About this Structure==

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[[Category: Gene v]]

[[Category: Mutant]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 12~~:47:36 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:01:39 2008''

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-[[Image:1vqc.jpg|left|200px]]
+{{Seed}}
+[[Image:1vqc.png|left|200px]]
 <!--
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 {{STRUCTURE_1vqc|  PDB=1vqc  |  SCENE=  }}
-'''GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY PHE 47 (V35I, I47F)'''
+===GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY PHE 47 (V35I, I47F)===
-==Overview==
+<!--
-The problem of rationally engineering protein molecules can be simplified where effects of mutations on protein function are additive. Crystal structures of single and double mutants in the hydrophobic core of gene V protein indicate that structural and functional effects of core mutations are additive when the regions structurally influenced by the mutations do not substantially overlap. These regions of influence can provide a simple basis for identifying sets of mutations that will show additive effects.
+The line below this paragraph, {{ABSTRACT_PUBMED_8855252}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8855252 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8855252}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Gene v]]
 [[Category: Mutant]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:47:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:01:39 2008''