1qw4: Difference between revisions

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[[Image:1qw4.jpg|left|200px]]
{{Seed}}
[[Image:1qw4.png|left|200px]]


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{{STRUCTURE_1qw4|  PDB=1qw4  |  SCENE=  }}  
{{STRUCTURE_1qw4|  PDB=1qw4  |  SCENE=  }}  


'''Crystal Structure of Murine Inducible Nitric Oxide Synthase Oxygenase Domain in complex with N-omega-propyl-L-arginine.'''
===Crystal Structure of Murine Inducible Nitric Oxide Synthase Oxygenase Domain in complex with N-omega-propyl-L-arginine.===




==Overview==
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The high level of amino acid conservation and structural similarity in the immediate vicinity of the substrate binding sites of the oxygenase domains of the nitric-oxide synthase (NOS) isoforms (eNOSoxy, iNOSoxy, and nNOSoxy) make the interpretation of the structural basis of inhibitor isoform specificity a challenge and provide few clues for the design of new selective compounds. Crystal structures of iNOSoxy and nNOSoxy complexed with the inhibitors W1400 and Nomega-propyl-l-arginine provide a rationale for their isoform specificity. It involves differences outside the immediate active site as well as a conformational flexibility in the active site that allows the adoption of distinct conformations in response to interactions with the inhibitors. This flexibility is determined by isoform-specific residues outside the active site.
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{{ABSTRACT_PUBMED_12954642}}


==About this Structure==
==About this Structure==
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[[Category: Schlichting, I.]]
[[Category: Schlichting, I.]]
[[Category: Inosoxy inhibitor complex]]
[[Category: Inosoxy inhibitor complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:46:04 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:20:07 2008''

Revision as of 20:20, 28 July 2008

File:1qw4.png

Template:STRUCTURE 1qw4

Crystal Structure of Murine Inducible Nitric Oxide Synthase Oxygenase Domain in complex with N-omega-propyl-L-arginine.

Template:ABSTRACT PUBMED 12954642

About this Structure

1QW4 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms., Fedorov R, Hartmann E, Ghosh DK, Schlichting I, J Biol Chem. 2003 Nov 14;278(46):45818-25. Epub 2003 Sep 3. PMID:12954642

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