1wd5: Difference between revisions

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[[Image:1wd5.jpg|left|200px]]
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[[Image:1wd5.png|left|200px]]


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{{STRUCTURE_1wd5|  PDB=1wd5  |  SCENE=  }}  
{{STRUCTURE_1wd5|  PDB=1wd5  |  SCENE=  }}  


'''Crystal structure of TT1426 from Thermus thermophilus HB8'''
===Crystal structure of TT1426 from Thermus thermophilus HB8===




==Overview==
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TT1426, from Thermus thermophilus HB8, is a conserved hypothetical protein with a predicted phosphoribosyltransferase (PRTase) domain, as revealed by a Pfam database search. The 2.01 A crystal structure of TT1426 has been determined by the multiwavelength anomalous dispersion (MAD) method. TT1426 comprises a core domain consisting of a central five-stranded beta sheet surrounded by four alpha-helices, and a subdomain in the C terminus. The core domain structure resembles those of the type I PRTase family proteins, although a significant structural difference exists in an inserted 43-residue region. The C-terminal subdomain corresponds to the "hood," which contains a substrate-binding site in the type I PRTases. The hood structure of TT1426 differs from those of the other type I PRTases, suggesting the possibility that TT1426 binds an unknown substrate. The structure-based sequence alignment provides clues about the amino acid residues involved in catalysis and substrate binding.
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{{ABSTRACT_PUBMED_15689504}}


==About this Structure==
==About this Structure==
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[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:23:36 2008''

Revision as of 20:23, 28 July 2008

File:1wd5.png

Template:STRUCTURE 1wd5

Crystal structure of TT1426 from Thermus thermophilus HB8

Template:ABSTRACT PUBMED 15689504

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a predicted phosphoribosyltransferase (TT1426) from Thermus thermophilus HB8 at 2.01 A resolution., Kukimoto-Niino M, Shibata R, Murayama K, Hamana H, Nishimoto M, Bessho Y, Terada T, Shirouzu M, Kuramitsu S, Yokoyama S, Protein Sci. 2005 Mar;14(3):823-7. Epub 2005 Feb 2. PMID:15689504

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