1o7y: Difference between revisions

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[[Image:1o7y.gif|left|200px]]
{{Seed}}
[[Image:1o7y.png|left|200px]]


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{{STRUCTURE_1o7y|  PDB=1o7y  |  SCENE=  }}  
{{STRUCTURE_1o7y|  PDB=1o7y  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF IP-10 M-FORM'''
===CRYSTAL STRUCTURE OF IP-10 M-FORM===




==Overview==
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We have determined the structure of wild-type IP-10 from three crystal forms. The crystals provide eight separate models of the IP-10 chain, all differing substantially from a monomeric IP-10 variant examined previously by NMR spectroscopy. In each crystal form, IP-10 chains form conventional beta sheet dimers, which, in turn, form a distinct tetrameric assembly. The M form tetramer is reminiscent of platelet factor 4, whereas the T and H forms feature a novel twelve-stranded beta sheet. Analytical ultracentrifugation indicates that, in free solution, IP-10 exists in a monomer-dimer equilibrium with a dissociation constant of 9 microM. We propose that the tetrameric structures may represent species promoted by the binding of glycosaminoglycans. The binding sites for several IP-10-neutralizing mAbs have also been mapped.
The line below this paragraph, {{ABSTRACT_PUBMED_12737818}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_12737818}}


==About this Structure==
==About this Structure==
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[[Category: Swaminathan, G J.]]
[[Category: Swaminathan, G J.]]
[[Category: Chemokine,interferon induction,chemotaxis,inflammatory response]]
[[Category: Chemokine,interferon induction,chemotaxis,inflammatory response]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:30:00 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:30:31 2008''
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