399d: Difference between revisions

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[[Image:399d.gif|left|200px]]
{{Seed}}
[[Image:399d.png|left|200px]]


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{{STRUCTURE_399d|  PDB=399d  |  SCENE=  }}  
{{STRUCTURE_399d|  PDB=399d  |  SCENE=  }}  


'''STRUCTURE OF D(CGCCCGCGGGCG)'''
===STRUCTURE OF D(CGCCCGCGGGCG)===




==Overview==
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We have determined the structure of the dodecamer duplex d(CGCCCGCGGGCG)2. A careful use of the molecular replacement programme AMoRe has been essential in order to solve the structure. This dodecamer shows a unique conformation, quite different from all the previously studied oligonucleotide duplexes: the central octamer has an A conformation, but with a sharp 65 degrees kink in the centre; the terminal base-steps have a B-like conformation; the major groove is completely closed in the centre, a hollow molecule is thus found. The results obtained confirm the high degree of variability of DNA structure. A new type of kink and an intermediate A/B double-helical conformation have been found. Such intermediate conformation differs from those described in DNA polymerase complexes.
The line below this paragraph, {{ABSTRACT_PUBMED_9917405}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9917405 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9917405}}


==About this Structure==
==About this Structure==
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[[Category: Malinina, J A.Subirana L.]]
[[Category: Malinina, J A.Subirana L.]]
[[Category: Double helix]]
[[Category: Double helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:18:58 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:36:39 2008''

Revision as of 20:36, 28 July 2008

File:399d.png

Template:STRUCTURE 399d

STRUCTURE OF D(CGCCCGCGGGCG)

Template:ABSTRACT PUBMED 9917405

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of the d(CGCCCGCGGGCG) dodecamer: a kinked A-DNA molecule showing some B-DNA features., Malinina L, Fernandez LG, Huynh-Dinh T, Subirana JA, J Mol Biol. 1999 Jan 29;285(4):1679-90. PMID:9917405

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