1thd: Difference between revisions

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[[Image:1thd.gif|left|200px]]
{{Seed}}
[[Image:1thd.png|left|200px]]


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{{STRUCTURE_1thd|  PDB=1thd  |  SCENE=  }}  
{{STRUCTURE_1thd|  PDB=1thd  |  SCENE=  }}  


'''COMPLEX ORGANIZATION OF DENGUE VIRUS E PROTEIN AS REVEALED BY 9.5 ANGSTROM CRYO-EM RECONSTRUCTION'''
===COMPLEX ORGANIZATION OF DENGUE VIRUS E PROTEIN AS REVEALED BY 9.5 ANGSTROM CRYO-EM RECONSTRUCTION===




==Overview==
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Dengue virus, a member of the Flaviviridae family, has a surface composed of 180 copies each of the envelope (E) glycoprotein and the membrane (M) protein. The crystal structure of an N-terminal fragment of E has been determined and compared with a previously described structure. The primary difference between these structures is a 10 degrees rotation about a hinge relating the fusion domain DII to domains DI and DIII. These two rigid body components were used for independent fitting of E into the cryo-electron microscopy maps of both immature and mature dengue viruses. The fitted E structures in these two particles showed a difference of 27 degrees between the two components. Comparison of the E structure in its postfusion state with that in the immature and mature virions shows a rotation approximately around the same hinge. Flexibility of E is apparently a functional requirement for assembly and infection of flaviviruses.
The line below this paragraph, {{ABSTRACT_PUBMED_15341726}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15341726 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15341726}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Conformational changes of the flavivirus E glycoprotein., Zhang Y, Zhang W, Ogata S, Clements D, Strauss JH, Baker TS, Kuhn RJ, Rossmann MG, Structure. 2004 Sep;12(9):1607-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15341726 15341726]
Conformational changes of the flavivirus E glycoprotein., Zhang Y, Zhang W, Ogata S, Clements D, Strauss JH, Baker TS, Kuhn RJ, Rossmann MG, Structure. 2004 Sep;12(9):1607-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15341726 15341726]
Visualization of membrane protein domains by cryo-electron microscopy of dengue virus., Zhang W, Chipman PR, Corver J, Johnson PR, Zhang Y, Mukhopadhyay S, Baker TS, Strauss JH, Rossmann MG, Kuhn RJ, Nat Struct Biol. 2003 Nov;10(11):907-12. Epub 2003 Oct 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14528291 14528291]
[[Category: Dengue virus 2]]
[[Category: Dengue virus 2]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Glycoprotein e]]
[[Category: Glycoprotein e]]
[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
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