2hkk: Difference between revisions

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[[Image:2hkk.~~jpg~~|left|200px]]

[[Image:2hkk.png|left|200px]]

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~~'''~~Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms~~'''~~

===Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms===

~~==Overview==~~

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The ~~activation of~~ the ~~metalloenzyme carbonic anhydrase~~ (~~CA, EC 4~~.2.1.1) with L-adrenaline and histamine has been investigated by kinetic and X-ray crystallographic studies. L-Adrenaline behaves as a potent activator of isozyme CA I (activation constant of 90 nM), being a much weaker activator of isozyme CA II (activation constant of 96 microM)~~. Isoforms CA IV~~, ~~VA, VII, and XIV were activated by L-adrenaline with K(A)s in~~ the ~~range of 36-63 microM~~. ~~The X~~-~~ray crystal structure of the CA II~~-~~L-adrenaline adduct revealed that the activator plugs the entrance of the active site cavity, obstructing it almost completely.~~

The line below this paragraph, {{ABSTRACT_PUBMED_17127057}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17127057 is the PubMed ID number.

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==About this Structure==

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[[Category: Carbonic anhydrase]]

[[Category: Crystal structure]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 06~~:24:05 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:48:43 2008''

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-[[Image:2hkk.jpg|left|200px]]
+{{Seed}}
+[[Image:2hkk.png|left|200px]]
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 {{STRUCTURE_2hkk|  PDB=2hkk  |  SCENE=  }}
-'''Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms'''
+===Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms===
-==Overview==
+<!--
-The activation of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) with L-adrenaline and histamine has been investigated by kinetic and X-ray crystallographic studies. L-Adrenaline behaves as a potent activator of isozyme CA I (activation constant of 90 nM), being a much weaker activator of isozyme CA II (activation constant of 96 microM). Isoforms CA IV, VA, VII, and XIV were activated by L-adrenaline with K(A)s in the range of 36-63 microM. The X-ray crystal structure of the CA II-L-adrenaline adduct revealed that the activator plugs the entrance of the active site cavity, obstructing it almost completely.
+The line below this paragraph, {{ABSTRACT_PUBMED_17127057}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17127057 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17127057}}
 ==About this Structure==
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 [[Category: Carbonic anhydrase]]
 [[Category: Crystal structure]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:24:05 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:48:43 2008''