1r2q: Difference between revisions

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[[Image:1r2q.~~gif~~|left|200px]]

[[Image:1r2q.png|left|200px]]

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~~'''~~Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution~~'''~~

===Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution===

~~==Overview==~~

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~~Rab5 is a GTPase that regulates early endosome fusion. Its GTPase domain crystal structure is reported here at 1.05 A resolution in complex with a GTP~~-~~analog molecule. It provides the highest resolution three~~-~~dimensional model so far obtained for proteins from~~ the ~~Ras-like GTPase family. This study allows extension of structural examination of~~ the ~~GTPase machinery~~ as ~~well as of high-resolution protein structures in general~~. ~~For example, a buried water-molecule network was observed underneath the switch regions~~, ~~which~~ is ~~consistent with~~ the ~~functional roles of these regions in the molecular~~-switching process. Furthermore, residues of multiple conformation and clustered distribution of anisotropic thermal motions of the protein molecule may have general implications for the function of Ras-~~like GTPases.~~

The line below this paragraph, {{ABSTRACT_PUBMED_14684892}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 14684892 is the PubMed ID number.

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==About this Structure==

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[[Category: Gtpase]]

[[Category: Rab]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 07~~:00:13 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:01:18 2008''

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-[[Image:1r2q.gif|left|200px]]
+{{Seed}}
+[[Image:1r2q.png|left|200px]]
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 {{STRUCTURE_1r2q|  PDB=1r2q  |  SCENE=  }}
-'''Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution'''
+===Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution===
-==Overview==
+<!--
-Rab5 is a GTPase that regulates early endosome fusion. Its GTPase domain crystal structure is reported here at 1.05 A resolution in complex with a GTP-analog molecule. It provides the highest resolution three-dimensional model so far obtained for proteins from the Ras-like GTPase family. This study allows extension of structural examination of the GTPase machinery as well as of high-resolution protein structures in general. For example, a buried water-molecule network was observed underneath the switch regions, which is consistent with the functional roles of these regions in the molecular-switching process. Furthermore, residues of multiple conformation and clustered distribution of anisotropic thermal motions of the protein molecule may have general implications for the function of Ras-like GTPases.
+The line below this paragraph, {{ABSTRACT_PUBMED_14684892}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14684892 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14684892}}
 ==About this Structure==
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 [[Category: Gtpase]]
 [[Category: Rab]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:00:13 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:01:18 2008''