2nqc: Difference between revisions

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[[Image:2nqc.jpg|left|200px]]
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[[Image:2nqc.png|left|200px]]


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{{STRUCTURE_2nqc|  PDB=2nqc  |  SCENE=  }}  
{{STRUCTURE_2nqc|  PDB=2nqc  |  SCENE=  }}  


'''Crystal structure of ig-like domain 23 from human filamin C'''
===Crystal structure of ig-like domain 23 from human filamin C===




==Overview==
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Filamin C is a dimeric, actin-binding protein involved in organization of cortical cytoskeleton and of the sarcomere. We performed crystallographic, small-angle X-ray scattering and analytical ultracentrifugation experiments on the constructs containing carboxy-terminal domains of the protein (domains 23-24 and 19-21). The crystal structure of domain 23 of filamin C showed that the protein adopts the expected immunoglobulin (Ig)-like fold. Small-angle X-ray scattering experiments performed on filamin C tandem Ig-like domains 23 and 24 reveal a dimer that is formed by domain 24 and that domain 23 has little interactions with itself or with domain 24, while the analytical ultracentrifugation experiments showed that the filamin C domains 19-21 form elongated monomers in diluted solutions.
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{{ABSTRACT_PUBMED_17379241}}


==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
[[Category: Metal binding]]
[[Category: Metal binding]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:46:43 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:01:40 2008''

Revision as of 21:01, 28 July 2008

File:2nqc.png


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2nqc, resolution 2.05Å (default scene)
Ligands: GOL, IMD, NI
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Crystal structure of ig-like domain 23 from human filamin C

Template:ABSTRACT PUBMED 17379241

About this Structure

2NQC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer., Sjekloca L, Pudas R, Sjoblom B, Konarev P, Carugo O, Rybin V, Kiema TR, Svergun D, Ylanne J, Djinovic Carugo K, J Mol Biol. 2007 May 11;368(4):1011-23. Epub 2007 Feb 20. PMID:17379241

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