2ihq: Difference between revisions

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[[Image:2ihq.jpg|left|200px]]
{{Seed}}
[[Image:2ihq.png|left|200px]]


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{{STRUCTURE_2ihq|  PDB=2ihq  |  SCENE=  }}  
{{STRUCTURE_2ihq|  PDB=2ihq  |  SCENE=  }}  


'''Crystal Structure of the Rat Androgen Receptor Ligand Binding Domian Complex with an N-Aryl-Hydroxybicyclohydantoin'''
===Crystal Structure of the Rat Androgen Receptor Ligand Binding Domian Complex with an N-Aryl-Hydroxybicyclohydantoin===




==Overview==
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A novel, N-aryl-bicyclohydantoin selective androgen receptor modulator scaffold was discovered through structure-guided modifications of androgen receptor antagonists. A prototype compound (7R,7aS)-10b from this series is a potent and highly tissue-selective agonist of the androgen receptor. After oral dosing in a rat atrophied levator ani muscle model, (7R,7aS)-10b demonstrated efficacy at restoring levator ani muscle mass to that of intact controls and exhibited &gt;50-fold selectivity for muscle over prostate.
The line below this paragraph, {{ABSTRACT_PUBMED_17181141}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17181141}}


==About this Structure==
==About this Structure==
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[[Category: Steroid receptor]]
[[Category: Steroid receptor]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:31:03 2008''
 
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