2iqc: Difference between revisions

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[[Image:2iqc.~~gif~~|left|200px]]

[[Image:2iqc.png|left|200px]]

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~~'''~~Crystal structure of Human FancF Protein that Functions in the Assembly of a DNA Damage Signaling Complex~~'''~~

===Crystal structure of Human FancF Protein that Functions in the Assembly of a DNA Damage Signaling Complex===

~~==Overview==~~

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~~Fanconi anemia (FA) is a rare autosomal recessive and X-linked chromosomal instability disorder. At least eight FA proteins (FANCA, B, C, E, F, G, L~~, ~~and M) form a nuclear core complex required for monoubiquitination of a downstream protein~~, ~~FANCD2. The human FANCF protein reportedly functions as a molecular adaptor within~~ the ~~FA nuclear complex, bridging between the subcomplexes A:G and C:E. Our x-ray crystallographic studies of the C-terminal domain of FANCF reveal a helical repeat structure similar~~ to the ~~Cand1 regulator of the Cul1-Rbx1-Skp1-Fbox~~(~~Skp2) ubiquitin ligase complex~~. ~~Two C-terminal loops of FANCF are essential for monoubiquitination of FANCD2 and normal cellular resistance to the DNA cross-linking agent mitomycin C~~. ~~FANCF mutants bearing amino acid substitutions in this C-terminal surface fail to interact with other components of the FA complex~~, ~~indicating that this surface~~ is ~~critical for~~ the ~~proper assembly of the FA core complex~~.

The line below this paragraph, {{ABSTRACT_PUBMED_17082180}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17082180 is the PubMed ID number.

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==Disease==

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[[Category: Fanconi]]

[[Category: Heat-like repeat]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 07~~:46:20 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:10:53 2008''

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-[[Image:2iqc.gif|left|200px]]
+{{Seed}}
+[[Image:2iqc.png|left|200px]]
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 {{STRUCTURE_2iqc|  PDB=2iqc  |  SCENE=  }}
-'''Crystal structure of Human FancF Protein that Functions in the Assembly of a DNA Damage Signaling Complex'''
+===Crystal structure of Human FancF Protein that Functions in the Assembly of a DNA Damage Signaling Complex===
-==Overview==
+<!--
-Fanconi anemia (FA) is a rare autosomal recessive and X-linked chromosomal instability disorder. At least eight FA proteins (FANCA, B, C, E, F, G, L, and M) form a nuclear core complex required for monoubiquitination of a downstream protein, FANCD2. The human FANCF protein reportedly functions as a molecular adaptor within the FA nuclear complex, bridging between the subcomplexes A:G and C:E. Our x-ray crystallographic studies of the C-terminal domain of FANCF reveal a helical repeat structure similar to the Cand1 regulator of the Cul1-Rbx1-Skp1-Fbox(Skp2) ubiquitin ligase complex. Two C-terminal loops of FANCF are essential for monoubiquitination of FANCD2 and normal cellular resistance to the DNA cross-linking agent mitomycin C. FANCF mutants bearing amino acid substitutions in this C-terminal surface fail to interact with other components of the FA complex, indicating that this surface is critical for the proper assembly of the FA core complex.
+The line below this paragraph, {{ABSTRACT_PUBMED_17082180}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17082180 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17082180}}
 ==Disease==
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 [[Category: Fanconi]]
 [[Category: Heat-like repeat]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:46:20 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:10:53 2008''