1oyi: Difference between revisions

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[[Image:1oyi.jpg|left|200px]]
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[[Image:1oyi.png|left|200px]]


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{{STRUCTURE_1oyi|  PDB=1oyi  |  SCENE=  }}  
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'''Solution structure of the Z-DNA binding domain of the vaccinia virus gene E3L'''
===Solution structure of the Z-DNA binding domain of the vaccinia virus gene E3L===




==Overview==
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The N-terminal domain of the vaccinia virus protein E3L (Z alpha(E3L)) is essential for full viral pathogenicity in mice. It has sequence similarity to the high-affinity human Z-DNA-binding domains Z alpha(ADAR1) and Z alpha(DLM1). Here, we report the solution structure of Z alpha(E3L) and the chemical shift map of its interaction surface with Z-DNA. The global structure and the Z-DNA interaction surface of Z alpha(E3L) are very similar to the high-affinity Z-DNA-binding domains Z alpha(ADAR1) and Z alpha(DLM1). However, the key Z-DNA contacting residue Y48 of Z alpha(E3L) adopts a different side chain conformation in unbound Z alpha(E3L), which requires rearrangement for binding to Z-DNA. This difference suggests a molecular basis for the significantly lower in vitro affinity of Z alpha(E3L) to Z-DNA compared with its homologues.
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{{ABSTRACT_PUBMED_14981270}}


==About this Structure==
==About this Structure==
1OYI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OYI OCA].  
1OYI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OYI OCA].  


==Reference==
==Reference==
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[[Category: Schmieder, P.]]
[[Category: Schmieder, P.]]
[[Category: Wecking, D A.]]
[[Category: Wecking, D A.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:26:08 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:27:07 2008''

Revision as of 21:27, 28 July 2008

File:1oyi.png

Template:STRUCTURE 1oyi

Solution structure of the Z-DNA binding domain of the vaccinia virus gene E3L

Template:ABSTRACT PUBMED 14981270

About this Structure

1OYI is a Single protein structure of sequence from Vaccinia virus. Full experimental information is available from OCA.

Reference

The solution structure of the N-terminal domain of E3L shows a tyrosine conformation that may explain its reduced affinity to Z-DNA in vitro., Kahmann JD, Wecking DA, Putter V, Lowenhaupt K, Kim YG, Schmieder P, Oschkinat H, Rich A, Schade M, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2712-7. Epub 2004 Feb 23. PMID:14981270

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