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| {{STRUCTURE_2gis| PDB=2gis | SCENE= }} | | {{STRUCTURE_2gis| PDB=2gis | SCENE= }} |
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| '''Structure of the S-adenosylmethionine riboswitch mRNA regulatory element'''
| | ===Structure of the S-adenosylmethionine riboswitch mRNA regulatory element=== |
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| ==Overview==
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| Riboswitches are cis-acting genetic regulatory elements found in the 5'-untranslated regions of messenger RNAs that control gene expression through their ability to bind small molecule metabolites directly. Regulation occurs through the interplay of two domains of the RNA: an aptamer domain that responds to intracellular metabolite concentrations and an expression platform that uses two mutually exclusive secondary structures to direct a decision-making process. In Gram-positive bacteria such as Bacillus species, riboswitches control the expression of more than 2% of all genes through their ability to respond to a diverse set of metabolites including amino acids, nucleobases and protein cofactors. Here we report the 2.9-angstroms resolution crystal structure of an S-adenosylmethionine (SAM)-responsive riboswitch from Thermoanaerobacter tengcongensis complexed with S-adenosylmethionine, an RNA element that controls the expression of several genes involved in sulphur and methionine metabolism. This RNA folds into a complex three-dimensional architecture that recognizes almost every functional group of the ligand through a combination of direct and indirect readout mechanisms. Ligand binding induces the formation of a series of tertiary interactions with one of the helices, serving as a communication link between the aptamer and expression platform domains.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16810258}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16810258 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16810258}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: S-adenosylmethionine]] | | [[Category: S-adenosylmethionine]] |
| [[Category: Sam]] | | [[Category: Sam]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:09:11 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:28:02 2008'' |
