1yk7: Difference between revisions

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[[Image:1yk7.gif|left|200px]]
{{Seed}}
[[Image:1yk7.png|left|200px]]


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{{STRUCTURE_1yk7|  PDB=1yk7  |  SCENE=  }}  
{{STRUCTURE_1yk7|  PDB=1yk7  |  SCENE=  }}  


'''Cathepsin K complexed with a cyanopyrrolidine inhibitor'''
===Cathepsin K complexed with a cyanopyrrolidine inhibitor===




==Overview==
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Starting from a PDE IV inhibitor hit derived from high throughput screening of the compound collection, a key pyrrolidine cyanamide pharmacophore was identified. Modifications of the pyrrolidine ring produced enhancements in cathepsin K inhibition. An X-ray co-crystal structure of a cyanamide with cathepsin K confirmed the mode of inhibition.
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{{ABSTRACT_PUBMED_15780613}}


==About this Structure==
==About this Structure==
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[[Category: Cysteine]]
[[Category: Cysteine]]
[[Category: Protease]]
[[Category: Protease]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:25:27 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:29:54 2008''

Revision as of 21:30, 28 July 2008

File:1yk7.png

Template:STRUCTURE 1yk7

Cathepsin K complexed with a cyanopyrrolidine inhibitor

Template:ABSTRACT PUBMED 15780613

About this Structure

1YK7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel and potent cyclic cyanamide-based cathepsin K inhibitors., Deaton DN, Hassell AM, McFadyen RB, Miller AB, Miller LR, Shewchuk LM, Tavares FX, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2005 Apr 1;15(7):1815-9. PMID:15780613

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