1s48: Difference between revisions

Line 1:

[[Image:1s48.~~gif~~|left|200px]]

[[Image:1s48.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Crystal structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from BVDV~~'''~~

===Crystal structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from BVDV===

~~==Overview==~~

<!--

The ~~bovine viral diarrhea virus (BVDV) RNA-dependent RNA polymerase can initiate RNA replication by a de novo mechanism without a primer. The structure of BVDV polymerase, determined to 2.9-A resolution~~, ~~contains a unique N-terminal domain~~, ~~in addition~~ to the ~~fingers, palm, and thumb domains common to other polymerases~~. ~~The structure of BVDV polymerase complexed with GTP~~, ~~which~~ is ~~required for de novo (primer-independent) initiation, shows that GTP binds adjacent to~~ the initiation NTP, suggesting that the GTP mimics a vestigial RNA product. Comparison of five monomers in two different crystal forms showed conformational changes in the fingertip region and in the thumb domain that may help to translocate the RNA template and product strands during elongation. The putative binding sites of previously reported BVDV inhibitors are also discussed.

The line below this paragraph, {{ABSTRACT_PUBMED_15070734}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15070734 is the PubMed ID number.

-->

==About this Structure==

Line 35:

Line 39:

[[Category: Primer independent initiation]]

[[Category: Rna virus]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 08~~:16:34 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:32:55 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1s48.gif|left|200px]]
+{{Seed}}
+[[Image:1s48.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1s48|  PDB=1s48  |  SCENE=  }}
-'''Crystal structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from BVDV'''
+===Crystal structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from BVDV===
-==Overview==
+<!--
-The bovine viral diarrhea virus (BVDV) RNA-dependent RNA polymerase can initiate RNA replication by a de novo mechanism without a primer. The structure of BVDV polymerase, determined to 2.9-A resolution, contains a unique N-terminal domain, in addition to the fingers, palm, and thumb domains common to other polymerases. The structure of BVDV polymerase complexed with GTP, which is required for de novo (primer-independent) initiation, shows that GTP binds adjacent to the initiation NTP, suggesting that the GTP mimics a vestigial RNA product. Comparison of five monomers in two different crystal forms showed conformational changes in the fingertip region and in the thumb domain that may help to translocate the RNA template and product strands during elongation. The putative binding sites of previously reported BVDV inhibitors are also discussed.
+The line below this paragraph, {{ABSTRACT_PUBMED_15070734}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15070734 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15070734}}
 ==About this Structure==
@@ Line 35: / Line 39: @@
 [[Category: Primer independent initiation]]
 [[Category: Rna virus]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:16:34 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:32:55 2008''