2fa0: Difference between revisions

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[[Image:2fa0.~~gif~~|left|200px]]

[[Image:2fa0.png|left|200px]]

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~~'''~~HMG-CoA synthase from Brassica juncea in complex with HMG-CoA and covalently bound to HMG-CoA~~'''~~

===HMG-CoA synthase from Brassica juncea in complex with HMG-CoA and covalently bound to HMG-CoA===

~~==Overview==~~

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3-~~Hydroxy~~-~~3-methylglutaryl CoA synthase (HMGS) catalyzes~~ the ~~first committed step in~~ the ~~mevalonate metabolic pathway for isoprenoid biosynthesis and serves~~ as ~~an alternative target for cholesterol-lowering and antibiotic drugs~~. ~~We have determined a previously undescribed crystal structure of a eukaryotic HMGS bound covalently to a potent and specific inhibitor F-244 [(E,E~~)~~-11-[3-(hydroxymethyl)-4-oxo-2-oxytanyl]-3~~,~~5,7-trimethyl-2,4-undecad ienenoic acid]~~. ~~Given the accessibility of synthetic analogs of the F~~-~~244 natural product, this inhibited eukaryotic HMGS structure serves as a necessary starting point for structure~~-~~based methods that may improve the potency and species-specific selectivity of the next generation of F-244 analogs designed to target particular eukaryotic and prokaryotic HMGS.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16864776}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16864776 is the PubMed ID number.

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==About this Structure==

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[[Category: Hmg-coa]]

[[Category: Hmgs1]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 03~~:38:50 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:35:16 2008''

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-[[Image:2fa0.gif|left|200px]]
+{{Seed}}
+[[Image:2fa0.png|left|200px]]
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 {{STRUCTURE_2fa0|  PDB=2fa0  |  SCENE=  }}
-'''HMG-CoA synthase from Brassica juncea in complex with HMG-CoA and covalently bound to HMG-CoA'''
+===HMG-CoA synthase from Brassica juncea in complex with HMG-CoA and covalently bound to HMG-CoA===
-==Overview==
+<!--
--Hydroxy-3-methylglutaryl CoA synthase (HMGS) catalyzes the first committed step in the mevalonate metabolic pathway for isoprenoid biosynthesis and serves as an alternative target for cholesterol-lowering and antibiotic drugs. We have determined a previously undescribed crystal structure of a eukaryotic HMGS bound covalently to a potent and specific inhibitor F-244 [(E,E)-11-[3-(hydroxymethyl)-4-oxo-2-oxytanyl]-3,5,7-trimethyl-2,4-undecad ienenoic acid]. Given the accessibility of synthetic analogs of the F-244 natural product, this inhibited eukaryotic HMGS structure serves as a necessary starting point for structure-based methods that may improve the potency and species-specific selectivity of the next generation of F-244 analogs designed to target particular eukaryotic and prokaryotic HMGS.
+The line below this paragraph, {{ABSTRACT_PUBMED_16864776}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16864776 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16864776}}
 ==About this Structure==
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 [[Category: Hmg-coa]]
 [[Category: Hmgs1]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:38:50 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:35:16 2008''