2gab: Difference between revisions

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[[Image:2gab.~~gif~~|left|200px]]

[[Image:2gab.png|left|200px]]

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~~'''~~Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-3,3',5,4'-tetrachlorobiphenyl~~'''~~

===Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-3,3',5,4'-tetrachlorobiphenyl===

~~==Overview==~~

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~~Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) are known to bind to transthyretin (TTR) in vitro~~, ~~possibly explaining their bioaccumulation~~, ~~rodent toxicity, and presumed human toxicity. Herein, we show that several OH-PCBs bind selectively~~ to ~~TTR in blood plasma; however, only one of~~ the ~~PCBs tested binds TTR in plasma~~. ~~Some of the OH-PCBs displace thyroid hormone (T4~~) ~~from TTR, rationalizing the toxicity observed in rodents~~, where ~~TTR~~ is the ~~major T4 transporter~~. ~~Thyroid binding globulin and albumin are the major T4 carriers in humans, making it unlikely that enough T4 could be displaced from TTR to be toxic. OH~~-~~PCBs are excellent TTR amyloidogenesis inhibitors in vitro because they bind to the TTR tetramer, imparting kinetic stability under amyloidogenic denaturing conditions. Four OH~~-~~PCB/TTR cocrystal structures provide further insight into inhibitor binding interactions.~~

The line below this paragraph, {{ABSTRACT_PUBMED_15610856}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15610856 is the PubMed ID number.

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==About this Structure==

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[[Category: Transthyretin]]

[[Category: Ttr]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 04~~:53:03 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:42:52 2008''

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-[[Image:2gab.gif|left|200px]]
+{{Seed}}
+[[Image:2gab.png|left|200px]]
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@@ Line 9: / Line 10: @@
 {{STRUCTURE_2gab|  PDB=2gab  |  SCENE=  }}
-'''Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-3,3',5,4'-tetrachlorobiphenyl'''
+===Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-3,3',5,4'-tetrachlorobiphenyl===
-==Overview==
+<!--
-Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) are known to bind to transthyretin (TTR) in vitro, possibly explaining their bioaccumulation, rodent toxicity, and presumed human toxicity. Herein, we show that several OH-PCBs bind selectively to TTR in blood plasma; however, only one of the PCBs tested binds TTR in plasma. Some of the OH-PCBs displace thyroid hormone (T4) from TTR, rationalizing the toxicity observed in rodents, where TTR is the major T4 transporter. Thyroid binding globulin and albumin are the major T4 carriers in humans, making it unlikely that enough T4 could be displaced from TTR to be toxic. OH-PCBs are excellent TTR amyloidogenesis inhibitors in vitro because they bind to the TTR tetramer, imparting kinetic stability under amyloidogenic denaturing conditions. Four OH-PCB/TTR cocrystal structures provide further insight into inhibitor binding interactions.
+The line below this paragraph, {{ABSTRACT_PUBMED_15610856}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15610856 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15610856}}
 ==About this Structure==
@@ Line 30: / Line 34: @@
 [[Category: Transthyretin]]
 [[Category: Ttr]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:53:03 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:42:52 2008''