1qsj: Difference between revisions

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[[Image:1qsj.gif|left|200px]]
{{Seed}}
[[Image:1qsj.png|left|200px]]


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{{STRUCTURE_1qsj|  PDB=1qsj  |  SCENE=  }}  
{{STRUCTURE_1qsj|  PDB=1qsj  |  SCENE=  }}  


'''N-TERMINALLY TRUNCATED C3DG FRAGMENT'''
===N-TERMINALLY TRUNCATED C3DG FRAGMENT===




==Overview==
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Complement component C3 plays a key role in the complement-mediated immune defence, and occupies a central position within the complement cascade system. One of its degradation products, C3dg, was purified from rat serum and crystallised in two different crystal forms as N-terminally truncated fragment. Despite the truncation and the lack of a significant portion of the N-terminus as compared to C3d, the structure of the fragment is highly similar to that of recombinant human C3d (Nagar et al., Science 280 (1998) 1277-1281). Structural details of the reactive site have been obtained, suggesting a possible mode of thioester bond formation between Cys-1010 and Gln-1013 and thioester bond cleavage in the transacylation reaction involving His-1126. The truncation at the N-terminus of C3d leads to the exposure of a surface of the molecule that favours dimerisation, so that in both crystal forms, the fragment is present as a dimer, with monomers related by a two-fold axis.
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{{ABSTRACT_PUBMED_10825534}}


==About this Structure==
==About this Structure==
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[[Category: Zanotti, G.]]
[[Category: Zanotti, G.]]
[[Category: Alpha-alpha barrel]]
[[Category: Alpha-alpha barrel]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:39:25 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:50:12 2008''

Revision as of 21:50, 28 July 2008

File:1qsj.png

Template:STRUCTURE 1qsj

N-TERMINALLY TRUNCATED C3DG FRAGMENT

Template:ABSTRACT PUBMED 10825534

About this Structure

1QSJ is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure at 1.44 A resolution of an N-terminally truncated form of the rat serum complement C3d fragment., Zanotti G, Bassetto A, Battistutta R, Folli C, Arcidiaco P, Stoppini M, Berni R, Biochim Biophys Acta. 2000 May 23;1478(2):232-8. PMID:10825534

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