1nm2: Difference between revisions

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[[Image:1nm2.jpg|left|200px]]
{{Seed}}
[[Image:1nm2.png|left|200px]]


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{{STRUCTURE_1nm2|  PDB=1nm2  |  SCENE=  }}  
{{STRUCTURE_1nm2|  PDB=1nm2  |  SCENE=  }}  


'''"Malonyl-CoA:ACP Transacylase"'''
==="Malonyl-CoA:ACP Transacylase"===




==Overview==
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Malonyl-CoA:ACP transacylase (MAT), the fabD gene product of Streptomyces coelicolor A3(2), participates in both fatty acid and polyketide synthesis pathways, transferring malonyl groups that are used as extender units in chain growth from malonyl-CoA to pathway-specific acyl carrier proteins (ACPs). Here, the 2.0 A structure reveals an invariant arginine bound to an acetate that mimics the malonyl carboxylate and helps define the extender unit binding site. Catalysis may only occur when the oxyanion hole is formed through substrate binding, preventing hydrolysis of the acyl-enzyme intermediate. Macromolecular docking simulations with actinorhodin ACP suggest that the majority of the ACP docking surface is formed by a helical flap. These results should help to engineer polyketide synthases (PKSs) that produce novel polyketides.
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{{ABSTRACT_PUBMED_12575934}}


==About this Structure==
==About this Structure==
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[[Category: Acetate bound to active site mimicking a malonyl group]]
[[Category: Acetate bound to active site mimicking a malonyl group]]
[[Category: Alpha/beta hydrolase-like core]]
[[Category: Alpha/beta hydrolase-like core]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:41:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:54:54 2008''

Revision as of 21:55, 28 July 2008

File:1nm2.png

Template:STRUCTURE 1nm2

"Malonyl-CoA:ACP Transacylase"

Template:ABSTRACT PUBMED 12575934

About this Structure

1NM2 is a Single protein structure of sequence from Bacteria. Full crystallographic information is available from OCA.

Reference

Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase., Keatinge-Clay AT, Shelat AA, Savage DF, Tsai SC, Miercke LJ, O'Connell JD 3rd, Khosla C, Stroud RM, Structure. 2003 Feb;11(2):147-54. PMID:12575934

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