2c0f: Difference between revisions

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[[Image:2c0f.gif|left|200px]]
{{Seed}}
[[Image:2c0f.png|left|200px]]


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{{STRUCTURE_2c0f|  PDB=2c0f  |  SCENE=  }}  
{{STRUCTURE_2c0f|  PDB=2c0f  |  SCENE=  }}  


'''STRUCTURE OF WIND Y53F MUTANT'''
===STRUCTURE OF WIND Y53F MUTANT===




==Overview==
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The structures of the PDI-related protein Wind (with a C-terminal His(6) tag) and the mutants Y53S, Y53F and Y55K have been determined and compared with the wild-type structure with the His(6) tag at the N-terminus. All five structures show the same mode of dimerization, showing that this was not an artefact introduced by the nearby N-terminal His(6) tag and suggesting that this dimer may also be the biologically active form. Although the mutants Y53S and Y55K completely abrogate transport of the protein Pipe (which appears to be the primary function of Wind in the cell), only subtle differences can be seen in the putative Pipe-binding region. The Pipe binding in the active forms appears to involve hydrophobic interactions between aromatic systems, whereas the inactive mutants may be able to bind more strongly with the help of hydrogen bonds, which could disturb the delicate equilibrium required for effective Pipe transport.
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{{ABSTRACT_PUBMED_16699185}}


==About this Structure==
==About this Structure==
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[[Category: Wind mutant]]
[[Category: Wind mutant]]
[[Category: Windbeutel]]
[[Category: Windbeutel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:55:54 2008''

Revision as of 21:55, 28 July 2008

File:2c0f.png

Template:STRUCTURE 2c0f

STRUCTURE OF WIND Y53F MUTANT

Template:ABSTRACT PUBMED 16699185

About this Structure

2C0F is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structural elucidation of the PDI-related chaperone Wind with the help of mutants., Sevvana M, Biadene M, Ma Q, Guo C, Soling HD, Sheldrick GM, Ferrari DM, Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):589-94. Epub 2006, May 12. PMID:16699185

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