1s8n: Difference between revisions

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[[Image:1s8n.gif|left|200px]]
{{Seed}}
[[Image:1s8n.png|left|200px]]


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{{STRUCTURE_1s8n|  PDB=1s8n  |  SCENE=  }}  
{{STRUCTURE_1s8n|  PDB=1s8n  |  SCENE=  }}  


'''Crystal structure of Rv1626 from Mycobacterium tuberculosis'''
===Crystal structure of Rv1626 from Mycobacterium tuberculosis===




==Overview==
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We describe the crystal structure of Rv1626 from Mycobacterium tuberculosis at 1.48 A resolution and the corresponding solution structure determined from small angle X-ray scattering. The N-terminal domain shows structural homology to the receiver domains found in bacterial two-component systems. The C-terminal domain has high structural homology to a recently discovered RNA binding domain involved in transcriptional antitermination. The molecule in solution was found to be monomeric as it is in the crystal, but in solution it undergoes a conformational change that is triggered by changes in ionic strength. This is the first structure that links the phosphorylation cascade of the two-component systems with the antitermination event in the transcriptional machinery. Rv1626 belongs to a family of proteins, which we propose calling phosphorylation-dependent transcriptional antitermination regulators, so far only found in bacteria, and includes NasT, a protein from the assimilatory nitrate/nitrite reductase operon of Azetobacter vinelandii.
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{{ABSTRACT_PUBMED_15341725}}


==About this Structure==
==About this Structure==
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[[Category: Transcriptional antiterminator]]
[[Category: Transcriptional antiterminator]]
[[Category: Two component system]]
[[Category: Two component system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:01:55 2008''

Revision as of 22:02, 28 July 2008

File:1s8n.png

Template:STRUCTURE 1s8n

Crystal structure of Rv1626 from Mycobacterium tuberculosis

Template:ABSTRACT PUBMED 15341725

About this Structure

1S8N is a Single protein structure of sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA.

Reference

The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis., Morth JP, Feng V, Perry LJ, Svergun DI, Tucker PA, Structure. 2004 Sep;12(9):1595-605. PMID:15341725

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