1vkx: Difference between revisions

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[[Image:1vkx.gif|left|200px]]
{{Seed}}
[[Image:1vkx.png|left|200px]]


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{{STRUCTURE_1vkx|  PDB=1vkx  |  SCENE=  }}  
{{STRUCTURE_1vkx|  PDB=1vkx  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THE NFKB P50/P65 HETERODIMER COMPLEXED TO THE IMMUNOGLOBULIN KB DNA'''
===CRYSTAL STRUCTURE OF THE NFKB P50/P65 HETERODIMER COMPLEXED TO THE IMMUNOGLOBULIN KB DNA===




==Overview==
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The NF-kappaB p50/p65 heterodimer is the classical member of the Rel family of transcription factors which regulate diverse cellular functions such as immune response, cell growth, and development. Other mammalian Rel family members, including the proteins p52, proto-oncoprotein c-Rel, and RelB, all have amino-terminal Rel-homology regions (RHRs). The RHR is responsible for the dimerization, DNA binding and cytosolic localization of these proteins by virtue of complex formation with inhibitor kappaB proteins. Signal-induced removal of kappaB inhibitors allows translocation of dimers to the cell nucleus and transcriptional regulation of kappaB DNA-containing genes. NF-kappaB specifically recognizes kappaB DNA elements with a consensus sequence of 5'-GGGRNYYYCC-3' (R is an unspecified purine; Y is an unspecified pyrimidine; and N is any nucleotide). Here we report the crystal structure at 2.9 A resolution of the p50/p65 heterodimer bound to the kappaB DNA of the intronic enhancer of the immunoglobulin light-chain gene. Our structure reveals a 5-base-pair 5' subsite for p50, and a 4-base-pair 3' subsite for p65. This structure indicates why the p50/p65 heterodimer interface is stronger than that of either homodimer. A comparison of this structure with those of other Rel dimers reveals that both subunits adopt variable conformations in a DNA-sequence-dependent manner. Our results explain the different behaviour of the p50/p65 heterodimer with heterologous promoters.
The line below this paragraph, {{ABSTRACT_PUBMED_9450761}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9450761 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9450761}}


==About this Structure==
==About this Structure==
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[[Category: Nf-kb]]
[[Category: Nf-kb]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:39:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:07:35 2008''

Revision as of 22:07, 28 July 2008

File:1vkx.png

Template:STRUCTURE 1vkx

CRYSTAL STRUCTURE OF THE NFKB P50/P65 HETERODIMER COMPLEXED TO THE IMMUNOGLOBULIN KB DNA

Template:ABSTRACT PUBMED 9450761

About this Structure

1VKX is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA., Chen FE, Huang DB, Chen YQ, Ghosh G, Nature. 1998 Jan 22;391(6665):410-3. PMID:9450761

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